OBJECTIVE Cannabinoid type 1 (CB1) receptor is involved in whole-body and cellular energy metabolism. We asked whether CB1 receptor stimulation was able to decrease mitochondrial biogenesis in different metabolically active tissues of obese high-fat diet (HFD)-fed mice. RESEARCH DESIGN AND METHODS The effects of selective CB1 agonist arachidonyl-2-chloroethanolamide (ACEA) and endocannabinoid...

BACKGROUND It has been shown that GH-deficient subjects tend to have fat accumulation. We have produced human GH (hGH) transgenic rats that exhibit low circulating hGH levels and hyperphagia. These rats are also characterized by severe obesity, hyperinsulinemia and hyperlipidemia. OBJECTIVE The present study was conducted in order to elucidate how excess caloric intake and impaired GH secreti...

This study examines in detail lightning activities over West Africa using the worldwide location network (WWLLN). The Worldwide Lightning Location Network (WWLLN; operated by University of Washington) is a developing, experimental detection increasingly used for applications. In Africa, there are many studies on diurnal process activity at regional level, but shortage literature examining varia...

There is a link between visceral white adipose tissue (WAT) and the metabolic syndrome in humans, with health improvements produced with small visceral WAT reduction. By contrast, subcutaneous WAT provides a site for lipid storage that is rather innocuous relative to ectopic lipid storage in muscle or liver. The sympathetic nervous system (SNS) is the principal initiator for lipolysis in WAT by...

Huntington's disease (HD) is a fatal, autosomal dominantly inherited neurodegenerative disorder, characterised not only by progressive cognitive, motor and psychiatric impairments, but also of peripheral pathology. In both human HD and in mouse models of HD there is evidence of increased energy expenditure and weight loss, alongside altered body composition. Unlike white adipose tissue (WAT), b...

We describe here our approaches and results on the WAT 2017 shared translation tasks. Motivated by the good results we obtained with Neural Machine Translation in the previous shared task, we continued to explore this approach this year, with incremental improvements in models and training methods. We focused on the ASPEC dataset and could improve the stateof-the-art results for Chinese-to-Japa...

Lipophilic pollutants can accumulate in human white adipose tissue (WAT), and the consequences of this accumulation are still poorly understood. Cytochromes P450 (P450s) have recently been found in rat WAT and shown to be inducible through mechanisms similar to those in the liver. The aim of our study was to describe the cytochrome P450 pattern and their induction mechanisms in human WAT. Expla...

OBJECTIVE White adipose tissue (WAT) and brown adipose tissue (BAT) play distinct roles in adaptation to changes in nutrient availability, with WAT serving as an energy store and BAT regulating thermogenesis. We previously showed that mice maintained on a leucine-deficient diet unexpectedly experienced a dramatic reduction in abdominal fat mass. The cellular mechanisms responsible for this loss...

Impaired visceral white adipose tissue (WAT) metabolism has been implicated in the pathogenesis of several lifestyle-related disease states, with diminished expression of several WAT mitochondrial genes reported in both insulin-resistant humans and rodents. We have used rat models selectively bred for low- (LCR) or high-intrinsic running capacity (HCR) that present simultaneously with divergent...

the effects of above and below-ground competition between chenopodium album and sugar beet (beta vulgaris) on growth, yield and quality of two sugar beet cultivars of morphologically contrasting growth habit have been investigated a factorial experiment (2 × 4) under glass-house conditions in a randomised complete block design with three replications was done. c. album and two sugar beet cultiv...