STUDY DESIGN System validation study. OBJECTIVE To develop and validate a motion sensor system for measuring cervical spine motion over extended time periods. SUMMARY OF BACKGROUND DATA Many studies using different methodologies have tried to estimate cervical spine motion. These have mostly been carried out in a laboratory setting performing active/passive range of motion or activities of ...

Wide binary stars with similar components hosting planets provide a favorable opportunity for exploring the star-planet chemical connection. We perform detailed characterization of solar-type in WASP-160 system. No planet has been reported yet around WASP-160A while WASP-160B is known to host transiting Saturn-mass planet, b. For this we also derive updated properties from both literature and n...

Short Abstract – Nephrin is a transmembrane protein essential for the formation of actin-based foot processes in glomerular podocytes. Its cytosolic domain contains three tyrosine motifs which recruit Nck, a SH3-SH3SH3-SH2 protein, upon phosphorylation. SH3 domains of Nck recruit WASP to form the Nephrin/Nck/WASP signalsome by binding the poly-proline motifs in WASP [1]. The multi-valences of t...

Microvilli are actin-based fingerlike membrane projections that form the basis of the brush border of enterocytes and the Drosophila melanogaster photoreceptor rhabdomere. Although many microvillar cytoskeletal components have been identified, the molecular basis of microvillus formation is largely undefined. Here, we report that the Wiskott-Aldrich syndrome protein (WASp) is necessary for rhab...

A female offspring of consanguineous parents, showed features of Wiskott-Aldrich syndrome (WAS), including recurrent infections, eczema, thrombocytopenia, defective T cell proliferation and chemotaxis, and impaired natural killer cell function. Cells from this patient had undetectable WAS protein (WASP), but normal WAS sequence and messenger RNA levels. WASP interacting protein (WIP), which sta...

Neuronal Wiskott-Aldrich syndrome protein (N-WASP)-activated actin polymerization drives extension of invadopodia and podosomes into the basement layer. In addition to activating Arp2/3, N-WASP binds actin-filament barbed ends, and both N-WASP and barbed ends are tightly clustered in these invasive structures. We use nanofibers coated with N-WASP WWCA domains as model cell surfaces and single-a...

Polymerization and organization of actin filaments into complex superstructures is indispensable for structure and function of neuronal networks. We here report that knock down of the F-actin-binding protein Abp1, which is important for endocytosis and synaptic organization, results in changes in axon development virtually identical to Arp2/3 complex inhibition, i.e., a selective increase of ax...

Wiskott-Aldrich syndrome (WAS) is a primary immunodeficiency that manifests as increased susceptibility to many pathogens. Although the spectrum of infections suffered by WAS patients is consistent with defects in neutrophil (PMN) function, the consequences of WAS protein (WASp) deficiency on this innate immune cell have been unclear. We report that deficiency of WASp in both human and murine P...

We examined 424 nests belonging to 61 wasp species along 5 km of rainforest edges in French Guiana (ca. 15,235 plants monitored), and estimate that we recorded up to 73% of the local social wasp fauna. This baseline study was complemented by a long-term survey of the same area and the examination of isolated trees (permitting us to record two additional species, resulting in a total of 63 wasp ...