AIM The aim of this study was to investigate the effect of two common herbal medicines, ginkgo and ginger, on the pharmacokinetics and pharmacodynamics of warfarin and the independent effect of these herbs on clotting status. METHODS This was an open label, three-way crossover randomized study in 12 healthy male subjects, who received a single 25 mg dose of warfarin alone or after 7 days pret...

Chronic dialysis patients frequently present with necrotic skin lesions. The differential diagnoses are broad and complex. The main focus of this paper is differentiating features of two diagnostic entities: Warfarin induced skin necrosis and calciphylaxis as early recognition and treatment may prevent the significant mortality. We discuss a case involving a hemodialysis patient, who developed ...

OBJECTIVE To determine whether warfarin can be safely administered to children who require long-term total parenteral nutrition (TPN), for the purpose of preventing central venous access device (CVAD)-related thrombosis. METHODS A prospective cohort study was conducted of 8 children with short-gut syndrome or small intestinal anomalies. All patients received oral anticoagulant therapy (warfar...

OBJECTIVE Matrix gla protein is a vitamin K-dependent inhibitor of medial arterial calcification whose synthesis and activity are blocked by warfarin. Warfarin induces arterial calcification in experimental models, but whether this occurs in humans is unclear. This was addressed by examining breast arterial calcification, which is exclusively medial and easily identified on mammograms. APPROA...

BACKGROUND: Cranberry products have been implicated in several case reports to enhance the anticoagulant effect of warfarin. The mechanism could involve inhibition of the hepatic CYP2C9-mediated metabolic clearance of warfarin by components in cranberry. Because dietary/natural substances vary substantially in bioactive ingredient composition, multiple cranberry products were evaluated in vitro...

Our understanding of human phase II metabolic pathways which facilitate detoxification and excretion of warfarin (Coumadin) is limited. The goal of this study was to test the hypothesis that there are specific human hepatic and extrahepatic UDP-glucuronosyltransferase (UGT) isozymes, which are responsible for conjugating warfarin and hydroxylated metabolites of warfarin. Glucuronidation activit...

BACKGROUND AND PURPOSE Stroke risk may increase shortly after warfarin initiation in nonvalvular atrial fibrillation patients. Because of the brief period and limited number of events, large samples are needed to study this effect. We compared 30-day rates of ischemic stroke between nonvalvular atrial fibrillation patients initiating warfarin to nonwarfarin comparators using an insurance claims...

a case to illustrate the utility of genetic screening in warfarin (Coumadin®) management is reported. a 45 year-old woman of puerto rican ancestry was admitted to the emergency room twice within one month with chest pain. she was diagnosed with congestive heart failure, which was stabilized both times. at her second release, warfarin therapy was initiated at 5 mg/ day to prevent thrombus format...

Diabetes mellitus (DM) is a chronic metabolic disease that characterized by elevated blood glucose levels. Warfarin an anticoagulant drug often used to treat and prevent microvascular macrovascular complications. This study wanted find out the effect of warfarin on tail bleeding time male Wistar rats with type 2 diabetes model. quasi-experimental posttest research design in vivo control group m...

We read with great interest the case by Leyh and associates on prosthetic valvular thrombosis in a pregnant patient anticoagulated with low-molecular-weight heparin (LMWH) [1]. Their case confirms once more the inefficacy of heparins to protect the mother from prosthetic valve thrombosis during pregnancy [2]. The usual management of anticoagulation in pregnant women is stopping warfarin adminis...