Adverse Drug Reactions (ADRs) and drug allergies- as a subset of ADRs- make a significant public health concern, complicating 5 to 15% of therapeutic drug courses. They may result in diminished quality of life, increased physician visits, health care costs, hospitalizations, and even death. The incidence of serious ADRs in hospitalized patients was estimated to be 6.7% and for fatal ADRs to be ...

PURPOSE To evaluate adverse drug reactions (ADRs) experienced by chronic myeloid leukemia (CML) patients during per oral tyrosine kinase inhibitor (TKI) treatment and correlation of ADR symptoms with medication adherence and perceived quality of life (QoL). PATIENTS AND METHODS Eighty-six adult, chronic-phase CML patients who had been on TKI treatment (79% on imatinib, 10.5% dasatinib, and 10...

AIMS To report a new strategy for the detection of hepatotoxic adverse drug reactions (ADRs) in hospitalized patients improving the results obtained with other methods. DESIGN The model is based on the identification of a single alert signal in various target clinical departments over a 12-month period. Each patient was later interviewed following a set protocol. The main results analyzed wer...

Medicines’ management is a priority in healthcare delivery, but weaknesses in the monitoring and management of Adverse Drug Reactions (ADRs) cause unplanned hospital admissions, financial burdens on healthcare systems, patient discomfort, morbidity, and mortality. This paper suggests policies and strategies that would help nurses minimise and manage ADRs to prescription medicines. The literatur...

With the advancements in Artificial intelligence (AI) and accumulation of healthrelated big data, it has become increasingly feasible commonplace to leverage machine learning technologies analyze clinical omics metadata assess possibility adverse drug reactions or events (ADRs) course discovery. Here, we have described a novel approach that combined drug-induced gene expression profile from Ope...

OBJECTIVE Medication  safety requires that each drug be monitored throughout its market life as early detection of adverse drug reactions (ADRs) can lead to alerts that prevent patient harm. Recently, electronic medical records (EMRs) have emerged as a valuable resource for pharmacovigilance. This study examines the use of retrospective medication orders and inpatient laboratory results documen...

Unwanted effects can occur with all medical interventions and most of these are adverse but this paper concentrates on adverse effects in randomised controlled trials (RCTs) of drug treatments. The process relies on a patient or health professional noticing and recording an adverse effect. Randomisation is the main tool for inferring causality and distinguishing between adverse events (co-incid...

BACKGROUND Adverse drug reactions (ADRs) are a significant cause of morbidity and mortality, with many being identified post-marketing. Improvement in current ADR reporting, including utility of underused or innovative methods, is crucial to improve patient safety and public health. OBJECTIVES To evaluate methods to improve ADR reporting via a systematic literature review. METHODS Data sour...

ABSTRACT Objectives: The drugs commonly used/prescribed by dentists/physicians or consumed patients may cause adverse drug reactions (ADRs). Therefore, the possibility of dentists to encounter an ADR during their professional lives cannot be underestimated and contribution pharmacovigilance systems notifying spontaneous reports play important role in early detection prevention ADRs. This study ...