نتایج جستجو برای: vivo

تعداد نتایج: 331386  

Journal: :Applied optics 2006
Gopalendu Pal Soumyadipta Basu Kunal Mitra Tuan Vo-Dinh

Our objective is to perform a comprehensive experimental and numerical analysis of the short-pulse laser interaction with a tissue medium with the goal of tumor-cancer diagnostics. For a short-pulse laser source, the shape of the output signal is a function of the optical properties of the medium, and hence the scattered temporal optical signal helps in understanding the medium characteristics....

Journal: :Optics express 2017
De Cai Zhongfei Li Yao Li Zhendong Guo Sung-Liang Chen

Acoustic-resolution photoacoustic microscopy (ARPAM) plays an important role in studying the microcirculation system of biological tissues with deep penetration. High lateral resolution of ARPAM is achieved by using a high numerical aperture acoustic transducer. The deteriorated lateral resolution in the out-of-focus region can be alleviated by synthetic aperture focusing technique (SAFT). Prev...

Journal: :Journal of biomedical optics 2001
B W Rice M D Cable M B Nelson

In vivo imaging of cells tagged with light-emitting probes, such as firefly luciferase or fluorescent proteins, is a powerful technology that enables a wide range of biological studies in small research animals. Reporters with emission in the red to infrared (>600 nm) are preferred due to the low absorption in tissue at these wavelengths. Modeling of photon diffusion through tissue indicates th...

2012
Hyewon Youn Kee-Jong Hong

The remarkable efforts that are made on molecular imaging technologies demonstrate its potential importance and range of applications. The generation of disease-specific animal models, and the developments of target-specific probes and genetically encoded reporters are another important component. Continued improvements in the instrumentation, the identification of novel targets and genes, and ...

Journal: :Physics in medicine and biology 2015
Jens Horstmann Hendrik Spahr Christian Buj Michael Münter Ralf Brinkmann

A full-field speckle interferometry method for non-contact and prospectively high speed Photoacoustic Tomography is introduced and evaluated as proof of concept. Thermoelastic pressure induced changes of the objects topography are acquired in a repetitive mode without any physical contact to the object. In order to obtain high acquisition speed, the object surface is illuminated by laser pulses...

2016
Toshiyuki Hamada Kenneth Sutherland Masayori Ishikawa Naoki Miyamoto Sato Honma Hiroki Shirato Ken-ichi Honma

Clock genes are expressed throughout the body, although how they oscillate in unrestrained animals is not known. Here, we show an in vivo imaging technique that enables long-term simultaneous imaging of multiple tissues. We use dual-focal 3D tracking and signal-intensity calibration to follow gene expression in a target area. We measure circadian rhythms of clock genes in the olfactory bulb, ri...

Journal: :Photonics 2014
Matthew D Risi Houssine Makhlouf Andrew R Rouse Anthony A Tanbakuchi Arthur F Gmitro

Confocal fluorescence microendoscopy provides high-resolution cellular-level imaging via a minimally invasive procedure, but requires fast scanning to achieve real-time imaging in vivo. Ideal confocal imaging performance is obtained with a point scanning system, but the scan rates required for in vivo biomedical imaging can be difficult to achieve. By scanning a line of illumination in one dire...

2016
Ann-Marie Waldron Leonie wyffels Jeroen Verhaeghe Jill C. Richardson Mark Schmidt Sigrid Stroobants Xavier Langlois Steven Staelens

We aimed to monitor the timing of amyloid-β deposition in relation to changes in brain function using in vivo imaging with [18F]-AV45 and [18F]-FDG in a mouse model of Alzheimer's disease. TASTPM transgenic mice and wild-type controls were scanned longitudinally with [18F]-AV45 and [18F]-FDG before (3 months of age) and at multiple time points after the onset of amyloid deposition (6, 9, 12, an...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2015
Rajeev V Rikhye Mriganka Sur

Intrinsic neuronal variability significantly limits information encoding in the primary visual cortex (V1). Certain stimuli can suppress this intertrial variability to increase the reliability of neuronal responses. In particular, responses to natural scenes, which have broadband spatiotemporal statistics, are more reliable than responses to stimuli such as gratings. However, very little is kno...

Journal: :The Review of scientific instruments 2003
David L Wokosin Jayne M Squirrell Kevin W Eliceiri John G White

Experimental laser microbeam techniques have become established tools for studying living specimens. A steerable, focused laser beam may be used for a variety of experimental manipulations such as laser microsurgery, optical trapping, localized photolysis of caged bioactive probes, and patterned photobleaching. Typically, purpose-designed experimental systems have been constructed for each of t...

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