Benzyl-substituted metallocarbene compounds synthesised by our group and others during the past 5 years give a new perspective on their activity as antibiotic and antitumoral drugs. N-heterocyclic carbenes containing an imidazole core were functionalised and their transition metal complexes (M = Ag, Au, Cu, Ru) have shown promising antibacterial as well as anticancer activity in vitro and in vi...

background drug resistance of microorganisms to antimicrobial agents is on the rise. therefore, an alternative route to overcome drug resistance of various microorganisms is needed. objectives this study was conducted to assess antibacterial activity of silver nanoparticles (agnps) produced by satureja hortensis extract against bacillus cereus isolated from soil of sistan plain (zabol, southeas...

Increasing bacterial resistance to commercial antibiotics has led to considering medicinal herb applications. This study aimed to identify chemical composition of essential oil of some native medical herbs and their antibacterial activity against Yersinia ruckeri compared with Enrofloxacin in in vitro experiments. The antibacterial activities of ethanolic extracts and essential oils of Eryngium...

Plants are rich source of antibacterial agents, which could be exploited in human disease management. Aqueous extracts of leaves of 46 plants selected based on an ethnobotanical survey from Mysore region Karnataka (India) were subjected to in vitro antibacterial activity assay against 14 important human pathogenic bacteria employing cup diffusion method. Antibacterial activity of the twelve pla...

Background: Klebsiella pneumoniae is one of the most important bacteria that cause nosocomial infections. This opportunistic pathogen has a high potential for antibiotic resistance and can generate a thick layer of biofilm. Nowadays, antibiotic resistant strains are emerging and widely spreading worldwide. Thus, it is necessary to combat drug-resistant strains through the use of novel drugs (su...

BACKGROUND Implant-related infections represent one of the most severe complications in orthopaedics. A fast-resorbable, antibacterial-loaded hydrogel may reduce or prevent bacterial colonization and biofilm formation of implanted biomaterials. QUESTIONS/PURPOSES We asked: (1) Is a fast-resorbable hydrogel able to deliver antibacterial compounds in vitro? (2) Can a hydrogel (alone or antibact...

Alpha-melanocyte stimulating hormone (alpha-MSH) is an endogenous anti-inflammatory peptide reported to possess antimicrobial properties, however their role as antibacterial peptides is yet to be established. In the present study, we examined in vitro antibacterial activity of alpha-MSH against S. aureus strain ISP479C and several methicillin-sensitive (MSSA) and methicillin-resistant (MRSA) S....