in this study, the essential oil obtained by hydrodistillation of the seeds of vitex pseudo-negundo (verbenaceae), growing wild in sabzevar, khorasan razavi province, iran, were analyzed by gc and gc/ms. the yield of total volatiles was 0.8% (w/w). thirty-seven compounds representing 92.4% of the seed oil were identified. the main components of the oil were hexadecanoic acid (8.0%), elemol (7.0...

A high performance liquid chromatography coupled with photodiode array detection method was developed for the identification and quantification of p-hydroxy benzoic acid and agnuside in the extracts of Vitex negundo and Vitex trifolia. The separation was achieved using acetonitrile and O-phosphoric acid-water (0.5%, v/v) as the mobile phase in an isocratic elution mode. Mean retention times of ...

The use of conventional drugs for the treatment pain and inflammation has largely resulted in various side effects. These challenges have triggered search alternative therapy such as herbal medication that may serve a safe, effective, alternate approach to managing inflammation. Vitex negundo, potential lipophilic molecule, possesses limited solubility permeability. Emulgels are either water-in...

Four phytoecdysteroids: (20-hydroxyecdysone-20, 22-monacetonide (1), 20-hydroxyecdysone (2), stigmasterol (3), gamma-sitosterol (4), were investigated for toxic effect against 3 rd /4 th instar larvae of Anopheles gambiae under laboratory conditions as individual compounds and in blends. The test larvae were treated with solutions containing the phytoecdysteroids of concentrations 1, 5 and 10pp...

The alcoholic and aqueous extracts of five medicinal plants (Cassia fistula, Albizia lebbeck, Cassia occidentalis , Sphaeranthus indicus and Vitex nigundo) collected from Uttarakhand, North India; were evaluated for antibacterial activity by Agar diffusion method against medically important bacteria viz. B. subtilis, K. pneumonia, E. coli, Enterobacter aerogenes, Pseudomonas aeruginosa, S. aure...

As part of our continuing efforts in the search for potential biologically active compounds from medicinal plants, we have isolated 18 compounds including two novel nitrogen containing diterpenes from extracts of the fruits of Vitex agnus-castus. These isolates, along with our previously obtained novel compound vitexlactam A (1), were evaluated for potential biological effects, including cancer...

Liver diseases such as jaundice, cirrhosis etc. are very common worldwide and traditional medicine are proving to be useless or less effective against them. Therefore workers are trying to find out alternate medicine or formulations to combat these diseases. In the present study hepatoprotective activity of aqueous extract of Adhatoda vasica and Vitex negundo on total protein, bilirubin, aspart...

Many women with PMS use alternative therapies, although there has been little research to demonstrate their efficacy. This systematic review provides a comprehensive discussion of dietary supplements and herbal remedies commonly used for premenstrual syndrome (PMS), including calcium, magnesium, vitamin B6, evening primrose oil, Vitex agnus castus, ginkgo biloba and St John’s Wort. Randomized c...

Vitex rotundifolia L. (VR) as long been used in China and Korea in traditional medicine. This study was conducted to evaluate the ability of Vitex rotundifolia L. to prevent airway inflammation and remodeling in an ovalbumin (OVA)-induced murine asthma model. The total cell number and number of inflammatory cells in the bronchoalveolar lavage (BAL) fluid were counted. The levels of cytokines in...