UNLABELLED Vitamin K (K) inadequacy may cause bone loss. Thus, K deficiency induced by anticoagulants (e.g., warfarin) may be an osteoporosis risk factor. The skeletal impact of long-term warfarin anticoagulation was evaluated in male monkeys. No effect on BMD or bone markers of skeletal turnover was observed. This study suggests that warfarin-induced K deficiency does not have skeletal effects...

Intact male and female albino rats fed a vitamin K-deficient diet develop a plasma prothrombin-proconvertin deficiency. Male rats respond with a precipitous drop to approximately 20-30% of normal plasma levels within 2-5 days, whereas female rats respond at a slower rate. Ethynylestradiol, 5-10 mug/day, or castration, reduces the progressive decline of plasma prothrombin-proconvertin seen in no...

We report a case of a 6-year-old girl with severe protein S deficiency due to a homozygous mutation and recurrent episodes of skin necrosis. She developed purpura fulminans at birth and a catheter-related venous thrombosis complicated by massive pulmonary embolism at the sixth day of life. Long-term oral anticoagulant therapy with a vitamin K-antagonist was started with a therapeutic range of t...

adds an important piece of understanding to the framework of the deranged vitamin K metabolism in CKD. A reduced GGCX activity in the kidneys and in the aorta (but not in the liver) of uremic animals was previously found by Kaesler et al. [3] , indicating that uremia per se affects the vitamin K system. In addition, supplementation of phylloquinone or menaquinone (MK-4) at pharmacological doses...

We report a rare case of acquired vitamin K deficiency presenting with severe menorrhagia and without any gynecological problem. Partial thromboplastin time (59.2 seconds) and prothrombin time (33.1 seconds, INR: 5.97) were considerably prolonged in laboratory evaluations. A complete coagulation factor assay test was performed for the patient: factor IX, 24%; factor II, 41%; factor VII, 3%; and...

six- to sixty months old children were studied in sirjan villages, divided into villages with or without a health house (hh). all the 893 children were medically examined and their food intake was assessed, using the 24-hours dietary recall method. ascorbic acid was determined in blood samples of 199 children. the results obtained are as follows: 1; the average vitamin c intake for all the chil...

Combined deficiency of factor (F)V and FVIII (F5F8D) and combined deficiency of vitamin K-dependent clotting factors (VKCFD) comprise the vast majority of reported cases of familial multiple coagulation factor deficiencies. Recently, significant progress has been made in understanding the molecular mechanisms underlying these disorders. F5F8D is caused by mutations in two different genes (LMAN1...

maternal vitamin d deficiency is one of the major risk factors for neonatal vitamin d deficiency followed by neonatal hypocalcaemia. the aim of this study is to determine the relationship between delayed neonatal hypocalcaemia and maternal vitamin d deficiency. this is a descriptive cross-sectional study. target population of this study included all term and preterm neonates with delayed hypoca...