Over 3 decades ago, Leber hereditary optic neuropathy (LHON) was the first condition found to be associated with a mitochondrial DNA mutation, and now remarkably it is inaugural disease undergo gene therapy trials. In this issue, Newman et al1Newman N.J. Yu-Wai-Man P. Carelli V. al.Efficacy safety of intravitreal for treated within 6 months onset.Ophthalmology. 2021; 128: 649-660Abstract Full T...