نتایج جستجو برای: virulence determinant
تعداد نتایج: 91096 فیلتر نتایج به سال:
Background: Virulence of pathogenic bacteria is often determined by their ability to adapt to stress. Result: The Brucella abortus general stress response (GSR) system is required for chronic mammalian infection, and is regulated by phosphorylation and proteolysis. Conclusion: The B. abortus GSR signaling pathway has multiple layers of post-translational control, and is a determinant of chronic...
The multi-resistant Staphylococcus capitis clone NRCS-A has recently been described as a major pathogen causing nosocomial, late-onset sepsis (LOS) in preterm neonates worldwide. NRCS-A representatives exhibit an atypical antibiotic resistance profile. Here, the complete closed genome (chromosomal and plasmid sequences) of NRCS-A prototype strain CR01 and the draft genomes of three other clinic...
Type-specificity of Group A streptococci is dependent upon the M antigen. This protein interferes with phagocytosis and is an important determinant of virulence.1 Recently some preparations of M protein have been shown to precipitate fibrinogen in vitro.' In an effort to find expression of this new biological property in vivo, M protein was injected into mice. The renal glomerular lesions obser...
The accepted paradigm states that anthrax is both an invasive and toxinogenic disease and that the toxins play a major role in pathogenicity. In the guinea pig (GP) model we have previously shown that deletion of all three toxin components results in a relatively moderate attenuation in virulence, indicating that B. anthracis possesses an additional toxin-independent virulence mechanism. To cha...
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