نتایج جستجو برای: viral dose
تعداد نتایج: 455392 فیلتر نتایج به سال:
background: we have validated the monitor unit calculations from a commercially available treatment planning system (tps) for three intensity modulated radiotherapy (imrt) planning techniques for tangential breast irradiation by using ionization chamber measurements. materials and methods: treatment plans were generated for forty-two breast patients by a forward planned field in field technique...
Natural killer (NK) cells are part of the innate immune system and recognize virus-infected cells as well as tumor cells. Conflicting data about the beneficial or even detrimental role of NK cells in different infectious diseases have been described previously. While the type of pathogen strongly influences NK cell functionality, less is known about how the infection dose influences the quality...
BACKGROUND Although the current standard of care for controlling anaemia and neutropenia during anti-viral therapy for hepatitis C is to use dose reduction of ribavirin and pegylated interferon, respectively, erythropoietin and granulocyte colony-stimulating factor are now being advocated as alternatives to dose reduction. AIM To determine the cost-effectiveness of erythropoietin and granuloc...
Four larval instars viz. II,III ,IV & V were fed on diet treated with four different concentrations i.e. 1x10, 1x10, 1x10, 1x10 POB/ml to evaluate highest mortality and maximum viral yield. Findings suggest that Ha-NPV should be applied to III instar larvae in vitro to achieve high larval mortality (78.33 %) and maximum viral yield (4.319 x10 POB/g of cadavar) at 1x10ml dose inoculum. Mortality...
BACKGROUND For patients with advanced hepatocellular carcinoma, sorafenib is the only approved drug worldwide, and outcomes remain poor. We aimed to assess the safety and efficacy of nivolumab, a programmed cell death protein-1 (PD-1) immune checkpoint inhibitor, in patients with advanced hepatocellular carcinoma with or without chronic viral hepatitis. METHODS We did a phase 1/2, open-label,...
BALB/c mice infected with human metapneumovirus (hMPV) were treated with the sulfated sialyl lipid NMSO3 (one dose of 50 mg kg(-1)) given at the time of infection. NMSO3 significantly reduced viral replication in the lungs, as well as hMPV-induced body weight loss, pulmonary inflammation and cytokine production, suggesting that antiviral treatment initiated at the beginning of viral infection c...
Although SARS-CoV-2-neutralizing antibodies are promising therapeutics against COVID-19, little is known about their mechanism(s) of action or effective dosing windows. We report the generation and development SC31, a potent SARS-CoV-2 neutralizing antibody, isolated from convalescent patient. Antibody-mediated neutralization occurs via an epitope within receptor-binding domain Spike protein. S...
BACKGROUND The aim of this study was to explore the predictive value of longitudinal self-reported adherence data on viral rebound. METHODS Individuals in the Swiss HIV Cohort Study on combined antiretroviral therapy (cART) with RNA <50 copies/ml over the previous 3 months and who were interviewed about adherence at least once prior to 1 March 2007 were eligible. Adherence was defined in term...
BACKGROUND Live attenuated influenza vaccine (LAIV) and inactivated influenza vaccine (IIV) are available for children. Local and systemic immunity induced by LAIV followed a month later by LAIV and IIV followed by LAIV were investigated with virus recovery after LAIV doses as surrogates for protection against influenza on natural exposure. METHODS Fifteen children received IIV followed by LA...
Viral diseases pose a significant threat to the productivity in aquaculture. Heart- and skeletal muscle inflammation (HSMI) is an emerging disease in Atlantic salmon (Salmo salar) farming. HSMI is associated with Piscine orthoreovirus (PRV) infection, but PRV is ubiquitous in farmed Atlantic salmon and thus present also in apparently healthy individuals. This has brought speculations if additio...
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