Systematic evaluations of the properties of prosthetic facial materials began to appear in 1969 with a report by Cantor et a/. ’ They reported that plasticized poly(methyl methacrylate) was the best material with respect to resistance to tearing and degree of elongation. A year later, Walter2 reported the specific gravity, water sorption, thermal conductivity, strain in compression, and permane...

Abstract Vinyl esters and carbonates have recently been demonstrated to considerably lower cytotoxicity than their more commonly used (meth)acrylate counterparts, inspiring use in the 3D printing of biomaterials. However, degradation rates such synthetic photopolymers are slow, especially mild conditions present many biological environments. Some applications, for example, tissue regeneration s...

Embedded optical fibre sensors (OFSs) offer the potential to monitor internal strains at various stages during manufacturing and service life of fibre-reinforced polymer (FRP) composite structures. Various aspects associated with embedment OFSs, such as integration, material compatibility, sensing performance embedded sensor needs be investigated develop reliable OFSs based platform for In this...

A method for the parallel solid-phase synthesis (SPS) of iodinated analogues of Sanofi-Aventis' type 1 cannabinoid (CB1) receptor inverse agonist rimonabant (acomplia) has been developed. The method allows the synthesis of a range of C3 amide/hydrazide derivatives from a resin-bound C3 ester precursor. The C-Ge linkage to the Hypogel-200 resin is stable to the diversification conditions but all...

Poly(ortho ester)s (POEs) are well-known for their surface-eroding properties and hence present unique opportunities for controlled-release and tissue-engineering applications. Their development and wide-spread investigation has, however, been severely limited by challenging synthetic requirements that incorporate unstable intermediates and are therefore highly irreproducible. Herein, the first...

The first enantioselective cross-electrophile coupling of aryl bromides with meso-epoxides to form trans-β-arylcycloalkanols is presented. The reaction is catalyzed by a combination of (bpy)NiCl2 and a chiral titanocene under reducing conditions. Yields range from 57 to 99% with 78-95% enantiomeric excess. The 30 examples include a variety of functional groups (ether, ester, ketone, nitrile, ke...