INTRODUCTION One of the main reasons for disease recurrence in the curative breast cancer treatment setting is the development of drug resistance. Microtubule targeted agents (MTAs) are among the most commonly used drugs for the treatment of breaset cancer and therefore overcoming taxane resistance is of primary clinical importance. Our group has previously demonstrated that the microtubule dyn...

the spotted amber ladybird, hippodamia variegata (col.: coccinellidae) is one of the most prominent coccinellid predators in iran. it is omnivorous and feed on aphids and psylla. the effects of two diets brevicoryne brassicae l. (hemiptera: aphididae)and eggs of ephestia kuehniella (lepidoptera: pyralidae) on some biological aspects of hippodamia variegata (goeze) (coleoptera: coccinellidae) we...

Vinflunine (VFL) is a third-generation bifluorinated semi-synthetic vinca alkaloid obtained by superacidic chemistry from its parent compound, vinorelbine. As with the other vinca alkaloids, the main antineoplastic effects of VFL arise from its interaction with tubulin, the major component of microtubules in mitotic spindles. In contrast to other vinca alkaloids, VFL shows some distinctive prop...

Background and objectives:Scrophularia variegata M. Beib. (Scrophulariaceae) is a medicinal plant, used for various inflammatory diseases in Iranian Traditional Medicine. In the present study, we evaluated the immune modulation and antioxidant effects of the hydroalcoholic extract of S.  variegata. Methods: The splenocytes were harvested...

background and objectives:scrophularia variegata m. beib. (scrophulariaceae) is a medicinal plant, used for various inflammatory diseases in iranian traditional medicine. in the present study, we evaluated the immune modulation and antioxidant effects of the hydroalcoholic extract of s.  variegata. methods: the splenocytes were harvested from the spleen of balb/c mice and were cultured. the spl...

Os artigos reunidos neste volume oferecem ao leitor uma perspectivação das formas como o horizonte tecnocultural contemporâneo vinca profundamente as práticas de criação literária. Nesse sentido, um problema recorrente consiste na busca modos apreensão conceitual fenômenos que esgarçam linhas imaginárias até então circunscreviam literárias.