Myosins play countless critical roles in the cell, each requiring it to be activated at a specific location and time. To control myosin VI with this specificity, we created an optogenetic tool for activating myosin VI by fusing the light-sensitive Avena sativa phototropin1 LOV2 domain to a peptide from Dab2 (LOVDab), a myosin VI cargo protein. Our approach harnesses the native targeting and act...

PURPOSE The aim of this study is to investigate the 4-year incidence and progression of visual impairment (VI) and the associated risk factors for incident VI in a South Indian population with type 2 diabetes. METHODS A total of 634 participants with type 2 diabetes were found eligible after 4 years. Visual acuity (VA) was estimated using the modified Early Treatment Diabetic Retinopathy Stud...

The adsorption of Cr(VI) on the raw multiwalled carbon nanotubes (MWCNTs) as a function of initial Cr(VI) concentration, pH, temperature, and MWCNT dosage were studied. The removal of Cr(VI) from aqueous solution was dominated by adsorption of Cr(VI) and redox reaction of Cr(VI) to Cr(III). The adsorption of Cr(VI) decreased with increasing pH and increased with the rise in temperature and MWCN...

Acrylonitrile (AN) and 1-vinyl imidazole (VI) based hydrogel was prepared in bulk (macro) dimensions via redox polymerization technique. Afterward, this quaternized (positively charged) exposed to the amidoximation reaction. The hydrogels (quart-p(AN-co-VI), amid-p(AN-co-VI) p(VI)) characterized using fourier transform infrared spectroscopy (FT-IR) thermal gravimetric analysis (TGA). Swelling e...

The effect of calcium on the dissolution and microbial reduction of a representative solid phase uranyl [U(VI)], sodium boltwoodite (NaUO(2)SiO(3)OH . 1.5H(2)O), was investigated to evaluate the rate-limiting step of microbial reduction of the solid phase U(VI). Microbial reduction experiments were performed in a culture of a dissimilatory metal-reducing bacterium (DMRB), Shewanella oneidensis ...

BACKGROUND Single-inhaler fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) 100/62.5/25 μg has been shown to improve lung function and health status, and reduce exacerbations, versus budesonide/formoterol in patients with chronic obstructive pulmonary disease (COPD). We evaluated the non-inferiority of single-inhaler FF/UMEC/VI versus FF/VI + UMEC using two inhalers. METHODS Eligible p...

background and objectives: because of toxical and hazardous properties of hexavalent chromium (cr(vi)), its removal by an economical and efficient method is necessary. the use of activated carbon, as an adsorbent, is a common and effective method for hexavalent chromium removal. thus the aim of this study was to produce granular and powdered activated carbon form peganum harmala and compare the...

background: in this study, ferrate (vi) and ultraviolet (uv) radiation were employed to remove hydrogen sulfide from municipal wastewater resulting in a reduction in chemical oxygen demand (cod). although ferrate (vi) and uv have been used individually for the removal of a few pollutants from urban and industrial wastewater, there exists no study to investigate the effectiveness of simultaneous...