With pronethalol, quinidine, and reserpine it was necessary to increase the dose of acetylstrophanthidin which produced arrhythmia in combination with vagal stimulation. However, in reserpine-treated animals, quinidine and pronethalol were ineffective. The capability of large doses of acetylstrophanthidin to produce ventricular arrhythmia was not diminished by quinidine, pronethalol, or reserpi...

With pronethalol, quinidine, and reserpine it was necessary to increase the dose of acetylstrophanthidin which produced arrhythmia in combination with vagal stimulation. However, in reserpine-treated animals, quinidine and pronethalol were ineffective. The capability of large doses of acetylstrophanthidin to produce ventricular arrhythmia was not diminished by quinidine, pronethalol, or reserpi...

The arrhythmogenic role of increased dispersion of repolarization (dispersion) was studied in 23 open-chest dogs using six simultaneously recorded monophasic action potentials (MAPs) from the ventricular surface and programmed ventricular premature stimulation (VPS). Increased dispersion was induced by generalized hypothermia (29 degrees C) and regional warm blood (38-43 degrees C) perfusion th...

What are tachycardiomyopathies? Tachycardiomyopathy is a relatively uncommon heart condition in which the myocardium develops ventricular dysfunction as consequence of persistently abnormal rhythm. One characteristics this that it partially or completely reversible, once arrhythmia has been controlled, making crucial to recognize adequately order make recovery function possible. In fact, term “...

BACKGROUND The purpose of this study was to determine the rate and causes of inappropriate rhythm detection, and to compare adequacy of ventricular arrhythmia detection by single-chamber and dual-chamber cardioverter-defibrillators (ICD). METHODS We evaluated 190 patients (age 57.2 +/- 11.2 years) with ICD. FOLLOW-UP 34.3 +/- +/- 22 months. Dual-chamber ICD was used in 54 patients. RESULT...

OBJECTIVES We administered pilsicainide chloride, a class Ic pure sodium channel blocker, to patients with Brugada syndrome (BS) and evaluated the occurrence of ventricular arrhythmia (VA) and T-wave alternans (TWA). BACKGROUND Ventricular arrhythmia and TWA are sometimes induced by a sodium channel blocker challenge test in BS patients, but the significance of the induced VA and TWA is not k...

BACKGROUND Although ventricular arrhythmia is critical for the prognosis of patients with severe congestive heart failure (CHF), it is difficult to control the arrhythmia using conservative therapies. However, many CHF patients also have sleep apnea syndrome (SAS) and oxygen supply improves their prognosis. The beneficial effects of oxygen treatment for ventricular arrhythmia have not yet been ...

Filamin C (FLNC) gene variants have been reported to be associated with arrhythmogenic cardiomyopathy (ACM), dilated (DCM), and sudden cardiac death. Currently left ejection fraction death risks do not appear clearly associated. FLNC DSP + tend show ring-shaped sub-epicardial scars. Although there is evidence suggest can cause arrhythmia or arrest, it continues as a variant of uncertain signifi...

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a lethal ventricular arrhythmia evoked by physical or emotional stress. Recessively inherited CPVT is caused by either missense or null-allele mutations in the cardiac calsequestrin (CASQ2) gene. It was suggested that defects in CASQ2 cause protein deficiency and impair Ca(2+) uptake to the sarcoplasmic reticulum and Ca(2+)-depende...