Vascular Endothelial Growth Factor (VEGF) plays an important role in tumor angiogenesis. Although several studies revealed on association of VEGF polymorphisms with gastric cancer, still the results are inconclusive.

Background: Determination of the impact of angiogenesis on tumor development and progression is essential. This study aimed to determine the serum levels of Vascular endothelial growth factor (VEGF) and Interleukin 6 (IL-6) in breast carcinoma, and to correlate them with tumor size, lymph node involvement, and cancer stage. Methods: Under aseptic precautions 5 ml of venous blood was collecte...

Introduction: Odontogenic tumors include a variety of lesions that are classified from hamartomas to benign and malignant neoplasms. Angiogenesis process helps neoplastic tissue to gain an adequate supply of oxygen and also to remove the waste products. Mean Vessel Density (MVD) evaluation is a common method for assessing angiogenesis by using different markers. To the best of our knowledge, t...

Vascular endothelial growth factor (VEGF) is a crucial regulator of physiological and pathological angiogenesis. Increased VEGF expression has been linked with inappropriate VEGF-induced angiogenesis in various disease pathologies including cancers. The aim present study was to investigate the role seven promoter polymorphisms [-417T/C (rs833062), -172C/A (rs59260042), -165C/T (rs79469752), -16...

Objective(s): microRNA-29 (miR-29) family miRNAs have been mentioned as tumor suppressive genes in several human cancers. The purpose of this study was to investigate the function of miR-29a in nasopharyngeal carcinoma (NPC) cells. Materials and Methods: Human NPC cell line 5-8F was transfected with mimic, inhibitor or scrambled controls...

Background: New blood vessels formation is a critical step in tumor progression. Vascular density affects the clinical outcome and prognosis of malignant tumors. The aim of this study was to investigate the relation between the Vascular Endothelial Growth Factor (VEGF) expression and vascular density with the clinical and histopathologic features in oral squamous cell carcinoma (OSCC). &nbsp...

Background: Oral lichen planus is a chronic inflammatory disease with a poorly understood etiology. The role of angiogenesis in the development of different chronic inflammatory diseases is of great concern. Vascular endothelial growth factor (VEGF) is an important regulator of angiogenesis. We aimed to evaluate the serum level of VEGF in patients with oral lichen planus compared with normal in...

Diabetic kidney disease (DKD) has become a global health concern, with about 40% of people living type 1 and 2 diabetes mellitus developing DKD. Upregulation vascular endothelial growth factor (VEGF) in the is significant pathology DKD associated increased glomerular permeability. To date, however, current anti-VEGF therapies have demonstrated limited success treating Recent studies shown that ...

Glioblastoma (GBM) is one of the most highly vascularized human cancers. The role exosomes in cancer angiogenesis has attracted recent interest. However, proangiogenic biomolecules transported by to facilitate GBM have not yet been identified. Here, we found a specific 120-kDa isoform vascular endothelial growth factor (VEGF) GBM-derived and confirmed it as VEGF-C. By binding VEGF receptor 2 (V...