OBJECTIVE To assess the expression of ICAM1, VCAM1, E-selectin, CD44, and TNF alpha in labial salivary glands of patients with rheumatoid vasculitis. METHODS Labial salivary glands from six patients with rheumatoid vasculitis before and after treatment, six aged matched rheumatoid arthritis patients without clinical evidence of rheumatoid vasculitis, 10 patients with primary Sjögren syndrome,...

SMAC antagonization of cIAP1/2 in TH17 cells upregulates cell adhesion and cytoskeleton genes through the NIK-RelB p52 axis. also increases homotypic interactions a non-canonical NF-κB- integrin-mediated mechanism resulting increased ability to withstand shear stress. T helper-17 (TH17) express transcription factor RORγt, produce IL-17 IL-22, are required for defense against extracellular patho...

Jin Ning Fang (JNF), a classic Chinese medicine formula, is widely used to treat lung cancer. However, its molecular mechanism remains unclear. Thus, we aimed explore the pharmacological mechanisms of JNF against targets and cancer-related genes were derived from public databases. Key compounds, potential therapeutic targets, pathways determined via bioinformatics analyses. Further, docking, in...

Background Extracellular vesicles (EVs) are membrane-coated most often generated from the vasculature and circulating blood cells upon cell activation during early phase of apoptosis (1). Objectives To evaluate concentration different subpopulations EVs in plasma patients with SSc relation to disease duration markers endothelial injury. Methods Our study included 59 (36 limited (lSSc) 23 diffus...