The innervation of the extrinsic uterine arterial supply of the guinea pig has been studied using an isolated perfused preparation. The preparation was normally at minimal tone and responded to periarterial stimulation by a vasoconstriction which was mimicked by norepinephrine and abolished by bretylium. Constrictor responses both to stimulation and to norepinephrine were similar in both pregna...

process of industrialization and urbanization. Woolf reveals the enduring roots of poverty in the disruptions offamily life by age, death, and illness, coupled with underemployment and subsistence wages, particularly for women, children, and the aged. He also explores the continuity in official attitudes towards poverty, and in the various strategies which became fashionable across Europe to co...

WHETHER AN ION CHANNEL ELEMENT could explain vasomotor responses that must inherently be coordinated among thousands of cells that comprise the blood vessels supplying end organs has been one of the deep puzzles in circulatory physiology for decades. In the recent article by Figueroa et al. (4), it is formulated into an ingenious presentation of microcirculatory function that promises to open a...

Vasoconstriction increases impedance to ventricular ejection and impairs the performance of the dilated myopathic heart. Vasodilator drug therapy by reducing vascular resistance, increasing vascular compliance and increasing vascular capacitance improves cardiac function and relieves the signs and symptoms of congestive heart failure. Earlier intervention in an attempt to alter the natural hist...

Vasodilating antihypertensive drugs have in common the capacity to activate the peripheral sympathetic nervous system through the carotid sinus baroreceptor reflex mechanism, thereby increasing heart rate, renin release, and sodium and water retention. They differ in their tendencies to augment cardiac output and to relieve or precipitate cardiac failure and arrhythmias. Vasodilating antihypert...

Cerebral Vasodilator Therapy in Stroke • Cerebral vasodilating agents have been questioned as an effective form of therapy for the stroke patient and even have been considered by some to be harmful. Animal studies show that often vasodilating agents will cause an intracerebral steal, but such a reaction has rarely been demonstrated in stroke patients. Several studies measuring cerebral blood fl...

Recognition of the value of glyceryl trinitrate (nitroglycerine) in the treatment and pr evention of anginal attacks has confirmed the belief that coronarv blood flow may be influenced favorablv by drug therapy and has led to a search for vasodilators capable of more prolonged action. The most popular of the newer agents which are alleged to have this desirable effect are Metamine, Paveril, Nit...