A realistic head model is needed for source localization methods used for the study of epilepsy in neonates applying Electroencephalographic (EEG) measurements from the scalp. The earliest models consider the head as a series of concentric spheres, each layer corresponding to a different tissue whose conductivity is assumed to be homogeneous. The results of the source reconstruction depend high...

The level set method is used for shape optimization of the energy functional for the Signorini problem. The boundary variations technique is used in order to derive the shape gradients of the energy functional. The conical differentiability of solutions with respect to the boundary variations is exploited. The topology modifications during the optimization process are identified by means of an ...

A standard approach for visualizing scalar volume data is the extraction of isosurfaces. The most efficient methods for surface extraction operate on regular grids. When data is given on unstructured point-based samples, regularization can be applied but may introduce interpolation errors. We propose a method for smooth isosurface visualization that operates directly on unstructured point-based...

A new variational PDE based level set method for a simultaneous image segmentation and non-rigid registration using prior shape and intensity information is presented. The segmentation is obtained by finding a non-rigid registration to the prior shape. The non-rigid registration consists of both a global rigid transformation and a local non-rigid deformation. In this model, a prior shape is use...

Protein–ligand binding is a key biological process at the molecular level. The identification and characterization of small-molecule binding sites on therapeutically relevant proteins have tremendous implications for target evaluation and rational drug design. In this work, we used the recently developed level-set variational implicit-solvent model (VISM) with the Coulomb field approximation (C...

Article history: Received 31 October 2009 Received in revised form 15 March 2010 Accepted 17 March 2010 Available online 21 March 2010

Image segmentation has always been a considerable challenge in image analysis and understanding due to the intensity inhomogeneity, which is also commonly known as bias field. In this paper, we present a novel region-based approach based on local entropy for segmenting images and estimating the bias field simultaneously. Firstly, a local Gaussian distribution fitting (LGDF) energy function is d...

In this paper, we study triply periodic surfaces with minimal surface area under a constraint in the volume fraction of the regions (phases) that the surface separates. Using a variational level set method formulation, we present a theoretical characterization of and a numerical algorithm for computing these surfaces. We use our theoretical and computational formulation to study the optimality ...

We present a novel geometric approach for solving the stereo problem for an arbitrary number of images (= or >2). It is based upon the definition of a variational principle that must be satisfied by the surfaces of the objects in the scene and their images. The Euler-Lagrange equations that are deduced from the variational principle provide a set of partial differential equations (PDE's) that a...

In this article, we systematically apply a novel implicit-solvent model, the variational implicit-solvent model (VISM) together with the Coulomb-Field Approximation (CFA), to calculate the hydration free energy of a large set of small organic molecules. Because these molecules have been studied in detail by molecular dynamics simulations and other implicit-solvent models, they provide a good be...