BACKGROUND Hyperbilirubinaemia is a major cause of neonatal morbidity. Early identification of those infants most at risk might allow the development of targeted primary preventative therapy and follow-up. The objective of this study was to assess whether arterial umbilical cord bilirubin (aUCB) level at delivery predicts the development of neonatal jaundice in term deliveries. METHODS Retros...

BACKGROUND Cardiopulmonary exercise testing (CPET) variables provide valuable prognostic information in the heart failure (HF) population. The purpose of the present study is to assess the ability of resting end-tidal carbon dioxide partial pressure (PETCO2) to predict cardiac-related events in patients with HF. METHODS 121 subjects diagnosed with compensated HF underwent CPET on an outpatien...

Three out of our five patients (cases 1-3) showed elevated ammonia serum levels. Very high ammonia levels have previously been described in patients with VE, even with normal liver function tests [21], and it has been hypothesised that the manifestations of VE are directly related to hyperammonaemia. VPA can increase the transport of glutamine across the mitochondrial membrane in the kidney, th...

BACKGROUND Passive leg raising (PLR) represents a "self-volume expansion (VE)" that could predict fluid responsiveness, but the influence of systolic cardiac function on PLR has seldom been reported. This study aimed to investigate whether systolic cardiac function, estimated by the global ejection fraction (GEF) from transpulmonary-thermodilution, could influence the diagnostic value of PLR. ...

Corporations face mounting maintenance and re-engineering costs for large legacy systems. Evolving over several years, these systems embody substantial corporate knowledge, including requirements, design decisions, and business rules. Such knowledge is di cult to recover after many years of operation, evolution, and personnel change. To address this problem, software engineers are spending an e...

OBJECTIVES The prevalence of chronic heart failure and a reduced ejection fraction (CHF-REF) has increased over the last decade. The cardiopulmonary exercise test (CPET) is an established tool for managing these patients. For patients who are administered beta-blockers, its predictive value is debated. The aim of this study was to assess the prognostic values of several parameters in patients w...