objective: epilepsy is a chronic neurological disorder requiring long term therapy using antiepileptic medications. reports have incriminated long term antiepileptic drugs use in deficiency of vitamin d and bone diseases in all age groups. to investigate the association between serum 25-hydroxyvitamin d levels and pediatric epilepsy in indian patients.           methods& methods: we prospective...

Because there is biochemical evidence of decreased GABAergic function in Parkinson's disease, sodium valproate, an inhibitor of GABA catabolism, was administered to eight Parkinsonian patients. Valproate treatment did not significantly alter any Parkinsonian feature, but tended to increase the dyskinesia in the "on-off" patients. The increased dyskinesias were not a result of altered peripheral...

The effect of sodium valproate (200 mg/kg body weight) on renal cells was investigated during a 10-day trial, by determining the catalytic activities of alanine aminopeptidase, gamma-glutamyltransferase and alkaline phosphatase in the membrane cell brush-border of the renal proximal tubules. Four days after the administration of sodium valproate, a significant increase was observed in the volum...

objectives juvenile myoclonic epilepsy(j.m.e.) needs life-long anti-epileptic drug (aed) treatment. of various drugs tried in this condition, valproate effectively treats all types of seizures seen in j.m.e. among valproate side effects, neural tube defects (ntd) in the offspring, is a deterring factor in its use in childbearing period. to avoid ntd, most authorities advise on switching to aed ...

ocular dryness is a well-recognized adverse side effect of many topical and systemic medications. in psychiatry, patients who have consumed such drugs as lithium carbonate and sodium valproate frequently experience dry eye symptoms. the purpose of this study was to compare tear film stability between patients who use these drugs with those patients who are not on medication.after obtaining info...