Enzymes play a fundamental role in almost all biological processes and identification of catalytic residues is a crucial step for deciphering the biological functions and understanding the underlying catalytic mechanisms. In this work, we developed a novel structural feature called MEDscore to identify catalytic residues, which integrated the microenvironment (ME) and geometrical properties of ...

In order to maximize throughput in end-system multicast, it is necessary to have fine-grained control over the transmit load of each participating member. This both avoids bottlenecks where members are overloaded, and allows heterogeneous members to contribute as much transmit capacity as they are able or willing to. In this paper, we describe and simulate an unstructured end-system multicast p...

Outlier detection and environmental association analysis are common methods to search for loci or genomic regions exhibiting signals of adaptation to environmental factors. However, a validation of outlier loci and corresponding allele distribution models through functional molecular biology or transplant/common garden experiments is rarely carried out. Here, we employ another method for valida...

In this papercable-based architectures are classified as active (i.e. cable parallel robots) and passive (wirebased measuring systems). For both classes the identification of applied/exerted wrenches is of fundamental importance for the use and feasible operation of the system. A suitable model and low-cost easy operation system for tension monitoring are proposed for experimental validation fo...

Abstract Probabilistic topic modeling algorithms like Latent Dirichlet Allocation (LDA) have become powerful tools for the analysis of large collections documents (such as papers, projects, or funding applications) in science, technology an innovation (STI) policy design and monitoring. However, selecting appropriate stable model a specific application (by adjusting hyperparameters algorithm) i...

In this paper we introduce the topic input validation, analyze its great importance to Web applications and suggest a new comprehensive approach to input validation. The approach has been developed as a result of an evaluation of current input validation approaches that showed that no sufficient solution to common input validation requirements is available at present. The paper describes import...

Structural variants are implicated in numerous diseases andmake up themajority of varying nucleotides among human genomes.Herewedescribe an integrated set of eight structural variant classes comprising both balanced andunbalanced variants, which we constructed using short-read DNA sequencing data and statistically phased onto haplotype blocks in 26 human populations. Analysing this set, we iden...

Structural variants are implicated in numerous diseases andmake up themajority of varying nucleotides among human genomes.Herewedescribe an integrated set of eight structural variant classes comprising both balanced andunbalanced variants, which we constructed using short-read DNA sequencing data and statistically phased onto haplotype blocks in 26 human populations. Analysing this set, we iden...

OBJECTIVES Declining participation in epidemiological studies has been reported in recent decades and may lead to biased prevalence estimates and selection bias. The aim of the study was to identify possible causes and effects of non-response in a population-based study of respiratory health in Norway. DESIGN The Telemark study is a longitudinal study that began with a cross-sectional survey ...