نتایج جستجو برای: vaccine efficacy
تعداد نتایج: 405191 فیلتر نتایج به سال:
Findings concerning influenza vaccine efficacy in young, healthy adults are inconsistent. A high incidence of influenza in the winter of 1995 provided an opportunity to study the efficacy of influenza vaccine among young, healthy military personnel. Influenza activity was confirmed by isolation of influenza A and B viruses from nasopharyngeal swab specimens from hospitalized soldiers. Self-admi...
Prospects for malaria eradication will be greatly enhanced by an effective vaccine, but parasite genetic diversity poses a major impediment to malaria vaccine efficacy. In recent pre-clinical and field trials, vaccines based on polymorphic Plasmodium falciparum antigens have shown efficacy only against homologous strains, raising the specter of allele-specific immunity such as that which plague...
BACKGROUND A number of countries in sub-Saharan Africa are preparing for HIV vaccine efficacy trials. Social and behavioural factors related to HIV transmission require examination in each setting where these trials are considered. As part of this, several countries have also recently begun preparatory research investigating relevant social and behavioural issues. There is a need for a review o...
Antigenic diversity has posed a critical barrier to vaccine development against the pathogenic blood-stage infection of the human malaria parasite Plasmodium falciparum. To date, only strain-specific protection has been reported by trials of such vaccines in nonhuman primates. We recently showed that P. falciparum reticulocyte binding protein homolog 5 (PfRH5), a merozoite adhesin required for ...
447 VOLUME 47__MAY 17, 2010 I refer to the article “Vi conjugate Typhoid Vaccine” written by Garg SP(1) on behalf of the manufacturer of Peda TyphTM in response to my previous article on the same subject(2). The author states that “this novel vaccine has been found to be safe and effective in inducing very high levels of immune response (>90%) in infants, young children and adults”, and goes fu...
OBJECTIVES We investigate the chance of demonstrating Ebola vaccine efficacy in an individually randomised controlled trial implemented in the declining epidemic of Forécariah prefecture, Guinea. METHODS We extend a previously published dynamic transmission model to include a simulated individually randomised controlled trial of 100,000 participants. Using Bayesian methods, we fit the model t...
BACKGROUND Increasing the number of vaccine doses may potentially improve overall efficacy. Decision-makers need information about choosing the most efficient dose schedule to maximise the total health gain of a population when operating under a constrained budget. The objective of this study is to identify the most efficient vaccine dosing schedule within a fixed vaccination budget from a heal...
هدف اصلی واکسنهای دامی بهبود و کنترل محصولات دامی و کاهش مصرف دارو و هورمون ها می باشد. ویروس بیماری تب برفکی باعث زیان های اقتصادی زیادی در دام ها می شود. مطالعات ایمونولوژیکی در ویروس تب برفکی نشان داده است که اپی توپ غالب مسئول القائ پاسخ آنتی بادی خنثی کننده، باقیمانده های آمینو اسیدی موجود در لوپ g-h هستند که لوپ سطحی پروتئین ساختمانی vp1 می باشد. واکسن رایج این بیماری به دلایلی چون نیمه ...
The control of ticks with vaccines is of global interest. Experimental vaccines incorporate new technologies as soon as they are available. Historically, the main vaccine studies have focused on the one-host cattle tick Rhipicephalus microplus, and efficacy evaluations have been standardised for this tick species. On the other hand, evaluations of vaccine candidates for three-host ticks are bei...
children under 2 years of age suffer from some of the highest rates of invasive pneumococcal disease (ipd) in the world. (turkey) rates of ipd had a decline after statewide introduction of the 7-valent pneumococcal conjugate vaccine (pcv7) in 2008. introduction of pcv7, pcv10 and pcv13 vaccines resulted in elimination of ipd caused by vaccine serotypes, but was followed by increasing rates of i...
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