First-generation adenovirus vectors (FG AdVs) expressing short-hairpin RNA (shRNA) effectively downregulate the expressions of target genes. However, this vector, in fact, expresses not only the transgene product, but also virus-associated RNAs (VA RNAs) that disturb cellular RNAi machinery. We have established a production method for VA-deleted AdVs lacking expression of VA RNAs. Here, we show...

The presence or absence of ventriculoatrial (VA) conduction in the human heart is assessed by investigating whether 1:1 retrograde atrial capture is observed during constant cycle length ventricular pacing. In this study, a new pacing protocol for assessing VA conduction was designed in which the ventricular extrastimulus was delivered during basic ventricular and atrial simultaneous pacing (VE...

Recent advances in Department of Veterans Affairs (VA) health care data systems have greatly increased access to operational pharmacy information. This article presents a brief guide to VA pharmacy data sources: the Veterans Health Information Systems and Technology Architecture files, the Pharmacy Benefits Management database, Decision Support System (DSS) National Data Extracts for inpatient ...

Chaharmahal and Bakhtiari Province is one of the 31 provinces of Iran and located on the southwestern part of the country. Its capital is Shahrekord. It has an area of 16,332 square kilometers and a population of 857,910. To study of human development used the Surplus Biocappacity (SB) and Human Development Index (HDI). This research accrued in the shahr-e-kord, Boroojen, Farsan, Ardal, Lordega...

Associated Infections Kyle Enfield, MD, MS; Costi D. Sifri, MD; Elizabeth Enfield, RN, MSN; Jessica Lewis, MD; Beth Quatrara, DNP, RN, CMSRN, ACNS-BC; Eve Giannetta, RN, BSN, CIC; Kristi Kimpel, RN, MSN; Kathleen Rea, RN, MSN; Department of Medicine, Division of Pulmonology, Hospital Epidemiology/Infection Prevention and Control, University of Virginia Health System, Charlottesville, VA; Depart...

BACKGROUND Ensuring veterans' access to healthcare is a national priority. Prior studies of veterans' use of Veterans Health Administration (VA) healthcare have had limited success in evaluating barriers to access for certain vulnerable veteran subpopulations. OBJECTIVES Our coalition of researchers and veteran community members sought to understand factors affecting use of VA, particularly f...

This study aimed to determine the incidence and the risk factors of hospitalization for variant angina (VA) in Korean patients. Using the National Inpatient Sample (NIS) database, manufactured and released by the Health Insurance Review and Assessment Service (HIRA) in Korea, the incidence of hospitalization and rehospitalization for VA were calculated. The numbers of patients hospitalized for ...

BACKGROUND Small intestinal biopsy with villous atrophy (VA) is the gold standard for the diagnosis of celiac disease (CD). We validated VA (Marsh 3) and small intestinal inflammation without VA (Marsh 1+2) in Swedish regional biopsy registers. METHODS All pathology departments in Sweden (n = 28) were searched to identify individuals with VA or duodenal/jejunal inflammation. The validation co...

A critical role for vitamin A (VA) in development is well established, but still relatively little is known about whole-body VA metabolism in early postnatal life. Recently, methods of mathematical modeling have begun to shed light on retinol kinetics in the postnatal growth period and on the effect of retinoid supplementation on retinol kinetics. Comparison of kinetic parameters from tracer st...