OBJECTIVE To investigate the potential value of combining uterine artery Doppler ultrasonography with the measurement of maternal serum pregnancy-associated plasma protein-A (PAPP-A), free beta-human chorionic gonadotropin (beta-hCG), activin A and inhibin A at 22 + 0 to 24 + 6 weeks' gestation, in the prediction of pregnancies that subsequently develop pre-eclampsia. METHODS The maternal ser...

OBJECTIVE To examine the role of second-trimester uterine artery Doppler in the prediction of stillbirths. METHODS Uterine artery pulsatility index (PI) was measured at 20-24 weeks' gestation in 65,819 singleton pregnancies. The PI was converted to multiples of median (MoM) and compared in live births and stillbirths. Regression analysis was used to determine the significance of association b...

BACKGROUND The transient effects of epidural bupivacaine 0.25-0.5% on the Doppler velocimetry of umbilical and uterine arteries had been reported, but the effects of continuous lower dose epidural bupivacaine (0.05-0.1%) infusion for labour analgesia have never been reported. In this study, we evaluated the effects of continuous epidural bupivacaine 0.075% on the Doppler velocimetry of uterine ...

OBJECTIVE The present study aimed to evaluate the effect of vaginal progesterone administration on maternal and fetal circulation to prevent preterm birth. METHODS The present prospective study was conducted on 35 women with singleton pregnancy at 18-33 weeks of gestation, who presented with at least one episode of preterm labor or asymptomatic short cervix, or past medical history of preterm...

Hypertensive disorder in pregnancy (HDP) is one of the major cause of maternal and perinatal mortality & morbidity worldwide particularly in developing countries. In developed countries, maternal mortality rate varies from 4-40 per 1 lakh live birth. In developing countries, it varies from 100-700 with India having 178 per 1 lakh live birth. Objective: Study of biochemical markers and uterine a...

34 35 The present study was conducted to determine the impact of suppressing trophoblast 36 remodeling of the uterine spiral arteries by prematurely elevating estrogen levels in the first 37 trimester of baboon pregnancy on uterine and umbilical blood flow dynamics. Uteroplacental 38 blood flow was assessed by Doppler ultrasonography after acute administration of saline (basal 39 state) and ser...

BACKGROUND Nitric oxide plays a major role in increasing uterine blood flow during the luteal phase and early pregnancy. This study was done to compare uterine artery and sub-endometrial blood flow indices during the luteal phase between patients with unexplained recurrent abortion and fertile women and also to evaluate the effects of nitric oxide donors on blood flow indices in the abortion gr...

Abstract To examine the effects of maternal nutrient restriction on net uteroplacental flux during mid-gestation, 14 singleton ewes (48.2 ± 4.0 kg body weight) were fed 100% (control; CON; n = 7) or 60% requirements (restricted; RES; from day 50–90 (mid-gestation). On 90, blood flow was measured via Doppler ultrasonography and samples collected femoral artery, uterine vein, umbilical vein. Bloo...

Possibility of hidden damages with temporary uterine artery occlusion device Sir, I read the article of Vilos et al. (2006) with interest, but I need to give some opinions about the use of this Doppler-guided transvaginal clamp. First, it is possible that the pelvic ureter will be occluded (Al-Awadi et al., 2005) when the transvagi-nal clamp closes. In this case, the ureter could be damaged, an...

The present study was conducted to determine the impact of suppressing trophoblast remodeling of the uterine spiral arteries by prematurely elevating estrogen levels in the first trimester of baboon pregnancy on uterine and umbilical blood flow dynamics. Uteroplacental blood flow was assessed by Doppler ultrasonography after acute administration of saline (basal state) and serotonin on days 60,...