gentamicin is an important aminoglycoside antibiotic. however its use is limited to serious and life threatening gram negative infections, because of its high nephrotoxicity potential in patients. there are reports that safranal, the active ingredient of saffron with antioxidant properties, exerts protective effect against ischemic injuries occurred by certain nephrotoxins including gentamicin....

BACKGROUND Better survival of thalassemia patients allowed previously unrecognized renal complications to emerge. OBJECTIVES Assess prevalence and early predictors of renal dysfunction in young β-thalassemia major (β-TM) and intermedia (β-TI) patients. SUBJECTS 66 β-TM (group I), 26 β-TI (group II) Egyptian patients and 40 healthy controls. METHODS Clinical assessment and laboratory data ...

We evaluated the usefulness of urinary nuclear matrix protein 22 (NMP22) compared to urinary cytology in the detection of urothelial transitional cell carcinoma (TCC). Between July 1999 and March 2000, 227 patients complaining of microscopic or gross hematuria were analyzed. Twenty-four patients (10.6%) had urothelial TCC. The urinary NMP22 level was significantly higher in the patients with ur...

conclusions multiple associations existed between atrophic urogenital changes and urinary incontinence. the most significant interaction was between urinary tract infections and urinary incontinence in menopausal women, with urinary tract infections increasing the risk of incontinence by 5.6 fold. we recommend health professionals to focus on early screening of these issues and implement educat...

a study was designed to evaluate the normal value of 24 hr urinary calcium levels in the city of yazd. the average urinary excretion of calcium in a sample of 329 persons randomly selected was 232 mg/day, while patients with a history of recurrent urolithiasis excreted 20x mg/day. there is evidence which shows that more important factors than the amount of urinary calcium exist which influence ...

BACKGROUND Tangshen Formula (TSF) is a traditional Chinese medicine for the treatment of diabetic kidney disease (DKD). Liver-type fatty acid binding protein (L-FABP) is expressed in various tissues, including the kidney, where it is known as urinary L-FABP. Other studies demonstrated that urinary L-FABP may be a useful biomarker for monitoring DKD. This post-hoc analysis and cross-sectional st...

In prevention stage, comparing with normal control group, triglycerides, blood sugar (BG), 24-hour urinary protein and cholesterol (CHO) were higher in T2DM group, but weight and urea nitrogen (BUN) was less in it. 24-hour urinary protein and cholesterol (CHO) were higher in T2DM group than the intervention group. 24-hour urinary protein and BG in the intervention group were higher than normal ...

Non-muscle-invasive bladder cancer (NMIBC) is one of the most common malignant tumors in the urological system with a high risk of recurrence, and effective non-invasive biomarkers for NMIBC relapse are still needed. The human urinary proteome can reflect the status of the microenvironment of the urinary system and is an ideal source for clinical diagnosis of urinary system diseases. Our previo...

Plasma levels vitamin K dependent coagulation factors, for example, prothrombin and protein C and urinary r-carboxyglutamic acid (r-Gla) were measured in diabetes mellitus. Concentration of prothrombin was determined by Echis carinatus-chromogenic method. (S-2238) and protein C was determined by ELISA. Concentration of urinary r-Gla was determined using HPLC by Kuwada, et. al. Plasma samples we...