Bisphenol A is an industrial chemical widely used in plastic products with a consequent exposure to humans. To assess whether exposure to bisphenol A is associated with renal disease, we searched for low-grade albuminuria in 3055 Chinese adults in the Shanghai metropolitan area aged 40 years or older. Using a value for urinary albumin-to-creatinine ratios <30 mg/g, we examined its association w...

BACKGROUND AND OBJECTIVES Insulin resistance has been shown to be closely associated with glomerular filtration rate and urinary albumin/creatinine ratio, even prior to the development of diabetes. Urinary kidney injury molecule 1 (KIM-1) is a novel, highly specific marker of kidney tubular damage. The role of insulin resistance in the development of kidney tubular damage is not previously repo...

INTRODUCTION Microalbuminuria has been now recognized as the most important risk factor for the increased morbidity and mortality in the obese population. OBJECTIVES We aimed to know whether severity of obesity is associated with the presence of renal injury while microalbuminuria acts, independent of other risk factors as hypertension and diabetes mellitus. PATIENTS AND METHODS The current...

diabetes mellitus (dm) is the most prevalent metabolic disease worldwide and is associated with coronary artery disease (cad). therefore it is very important to find a clue to diagnose the presence of cad as early as possible in dm patients. the aim of this study was to find any correlation between microalbuminuria (mau) and the severity of cad in patients with dm type 2. this was a cross secti...

Recently, several renal tubular damage markers have gained considerable attention because of their clinical implications as sensitive and specific biomarkers for early stage diabetic kidney disease. However, little is known about the demographic and glucometabolic factors affecting levels of urinary N-acetyl-β-D-glucosaminidase (NAG), a marker of proximal tubular damage, in type 2 diabetes mell...

We describe microplate methods for measurement of human urinary albumin (HUA) by competitive enzyme-linked immunosorbant assay (ELISA) and creatinine with a modified commercial enzymatic kit. Incorporation of substrate mixing into the competitive ELISA changes the dynamic absorbance-concentration response, greatly simplifying calculations and improving sensitivity and accuracy. Measurement of c...