A simple approach based on cyclic voltammetry (CV) was developed for the simultaneous determination of dopamine (DA) and uric acid (UA) in the presence of ascorbic acid (AA) using a modified glassy carbon paste electrode (GCPE). In the present study, analytical parameters were optimized and electrochemical performance of modified electrode was investigated. The calibration curves were obtained ...

BACKGROUND Bryophyllum pinnatum, commonly known as Pattharcaṭṭa, is used traditionally in ethnomedicinal practices for the treatment of kidney stone and urinary insufficiency. AIM The present study evaluated the effect of Bryophyllum pinnatum on ethylene glycol (EG)-induced renal calculi in rats. MATERIALS AND METHODS Renal calculi were induced in rats by administration of 0.75% EG in drink...

OBJECTIVES The aim was to evaluate the adsorbing effect of montmorillonite on uric acid, promoting diffusion of uric acid from blood to intestine, preventing absorption of uric acid in intestine and reducing uric acid level in serum. METHODS The adsorbing effect of montmorillonite on uric acid was observed in vitro. The intestine and blood vessel of rats were circularly perfused with intestin...

Background: The incidence and prevalence of urinary stone are increasing throughout the world. Compared with the past, urolithiasis compositions by patient demographics are strikingly different. Furthermore, recent clinical studies implied that seasonal cyclicity might influence the distribution of stone composition. Methods: We sought to determine the trends in pathogenesis of urolithiasis bas...

BACKGROUND Studies that evaluate the effect of age on stone composition are scarce. The aim of this study was to highlight the changes in epidemiological characteristics (stone composition and location) of urolithiasis according to patients' age. METHODS We studied 1,301 urolithiasis patients with age ranging from 6 months to 92 yr (781 males and 520 females). Stone analysis was performed usi...

Objective(s): Hyperuricemia is a risk for cardiovascular and metabolic diseases, but the mechanism is ambiguous. Increased intestinal permeability is correlated with metabolic syndrome risk factors. Intestinal epithelial cells play a pivotal role in maintaining intestinal permeability. Uric acid is directly eliminated into intestinal lumen, however, the mechanism and e...

BACKGROUND The incidence and prevalence of urinary stone are increasing throughout the world. Compared to the past, recent demographics of patient with urolithiasis compositions are strikingly different. Furthermore, recent clinical studies implied that seasonal cyclicity might influence the distribution of stone composition. METHODS We sought to determine the trends in pathogenesis of urolit...

BACKGROUND It is well known that many diseases may be associated with obesity resulting from an energy-rich diet, and that a westernized diet may increase the incidence of urinary stone formation. To evaluate degree of obesity, we investigated body mass index (BMI) in patients with calcium containing upper urinary stones and examined their blood with regard to lipid metabolism. METHODS Betwee...