Tumoral or nodular melanosis in the skin is considered a variation of completely regressed melanoma, presenting clinically as a suspicious pigmented papule or nodule. Microscopically, the lesion consists of a nodular accumulation of heavily pigmented melanophages in the dermis, staining positive for immunohistochemical markers of histiocytic lineage (CD68) and negative for those of melanocytic ...

A 20-year-old white female, who is an avid tanning-bed user, was referred for the evaluation of a pigmented lesion in her left eye. She reported occasional lid swelling, pain, tearing and light sensitivity for two years, which she attributed to wearing contact lenses. The patient received a diagnosis of ocular melanosis 6 months prior to her current presentation. On examination, the best-correc...

Melanosis of the urinary bladder is very rare. It is characterized by the deposition of melanin within the vesical urothelium and/ or lamina propria without the presence of melanocytes [1]. It is a distinct pathological entity in its own right and is not directly related to other melanotic lesions such as melanocytic naevus, lentigo maligna or malignant melanoma. At present, melanosis of the bl...

This short report discusses a case of solitary colonic polypoid ganglioneuroma associated with melanosis coli in a woman with no systemic manifestations. To our knowledge this is the first ganglioneuroma reported in the literature in association with melanosis coli. The nature and significance of this event remains unclear, although this may be coincidental due to the laxative intake. Further i...

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