conventional transdermal drug delivery systems (tdds) have been designed for drug delivery through the skin. these systems use the permeability property of stratum corneum, the outermost surface layer of the skin. applying polymeric micro and nanofibers in drug delivery has recently attracted great attention and the electrospinning technique is the preferred method for polymeric micro-nanofiber...

scaffold design has pivotal role in tissue engineering. in the present study, we modified the surface of electrospun poly(caprolactone) (pcl) nanofibers to improve their compatibility with living medium and to show the potential application of pcl nanofibers as a artificial extracellular matrix using in tissue-engineering. pcl nanofibers were fabricated by electrospinning method. to graft gelat...

tissue engineering is defined as the designing and engineering of structures to rebuild and repair a body damaged tissue. scaffolding poly hydroxy butyrate valraty (phbv) has shown good biocompatibility and biodegradable properties. nanofibers have improved the performance of biomaterials, and could be considered effective. one of the important methods for designing nanofiber scaffold is the el...

A nanofabrication method for the production of flexible core-shell structured silk elastin nanofibers is presented, based on an all-aqueous coaxial electrospinning process. In this process, silk fibroin (SF) and silk-elastin-like protein polymer (SELP), both in aqueous solution, with high and low viscosity, respectively, were used as the inner (core) and outer (shell) layers of the nanofibers. ...

In the present study, we had introduced polyurethane (PU) nanofibers that contain hydroxyapatite (HAp) nanoparticles (NPs) as a result of an electrospinning process. A simple method that does not depend on additional foreign chemicals had been employed to synthesize HAp NPs through the calcination of bovine bones. Typically, a colloidal gel consisting of HAp/PU had been electrospun to form nano...

Here we demonstrate the combination of electrospinning and hollow cathode plasma-assisted atomic layer deposition (HCPA-ALD) processes by fabricating flexible polymer–GaN organic–inorganic core–shell nanofibers at a processing temperature much lower than that needed for the preparation of conventional GaN ceramic nanofibers. Polymer–GaN organic–inorganic core–shell nanofibers fabricated by the ...

The novel method, handspinning (HS), was invented by mimicking commonly observed methods in our daily lives. The use of HS allows us to fabricate carbon nanotube-reinforced nanofibers (CNT-reinforced nanofibers) by addressing three significant challenges: (i) the difficulty of forming nanofibers at high concentrations of CNTs, (ii) aggregation of the CNTs, and (iii) control of the orientation o...

Functionalized electrospun nanofibers were integrated into microfluidic channels to serve as on-chip bioseparators. Specifically, poly(vinyl alcohol) (PVA) nanofiber mats were shown to successfully serve as bioseparators for negatively charged nanoparticles. Nanofibers were electrospun onto gold microelectrodes, which were incorporated into poly(methyl methacrylate) (PMMA) microfluidic devices ...

Ferulic acid (FA) is a polyphenolic phytonutrient which possesses strong antiproliferative effect; however, it has limited therapeutic applications due to its physiochemical instability and low bioavailability at the tumor site. In present study, these shortcomings associated with FA were overcome by fabricating FA-encapsulated poly(D,L-lactide-co-glycolide)/polyethylene oxide (PLGA/PEO) blend ...