نتایج جستجو برای: unc immunohistochemistry in unc

تعداد نتایج: 16977827  

2013
Osama Refai Patricia Rohs Paul E. Mains Jeb Gaudet

The guidance of axons to their correct targets is a critical step in development. The C. elegans pharynx presents an attractive system to study neuronal pathfinding in the context of a developing organ. The worm pharynx contains relatively few cells and cell types, but each cell has a known lineage and stereotyped developmental patterns. We found that extension of the M1 pharyngeal axon, which ...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2003
Eleanor A Mathews Esperanza García Celia M Santi Gregory P Mullen Colin Thacker Donald G Moerman Terrance P Snutch

The Caenorhabditis elegans unc-2 gene encodes a voltage-gated calcium channel alpha1 subunit structurally related to mammalian dihydropyridine-insensitive high-threshold channels. In the present paper we describe the characterization of seven alleles of unc-2. Using an unc-2 promoter-tagged green fluorescent protein construct, we show that unc-2 is primarily expressed in motor neurons, several ...

Journal: :Current Biology 2006
Chieh Chang Carolyn E. Adler Matthias Krause Scott G. Clark Frank B. Gertler Marc Tessier-Lavigne Cornelia I. Bargmann

BACKGROUND The cytoplasmic C. elegans protein MIG-10 affects cell migrations and is related to mammalian proteins that bind phospholipids and Ena/VASP actin regulators. In cultured cells, mammalian MIG-10 promotes lamellipodial growth and Ena/VASP proteins induce filopodia. RESULTS We show here that during neuronal development, mig-10 and the C. elegans Ena/VASP homolog unc-34 cooperate to gu...

Journal: :Genetics 1995
W Shreffler T Magardino K Shekdar E Wolinsky

Two Caenorhabditis elegans genes, unc-8 and sup-40, have been newly identified, by genetic criteria, as regulating ion channel function in motorneurons. Two dominant unc-8 alleles cause motorneuron swelling similar to that of other neuronal types in dominant mutants of the deg-1 gene family, which is homologous to a mammalian gene family encoding amiloride-sensitive sodium channel subunits. As ...

Journal: :Development 1998
A Duggan C Ma M Chalfie

The nematode Caenorhabditis elegans possesses six morphologically similar neurons that are responsible for sensing gentle touch to the body. Previous genetic studies identified genes that are necessary for the production and differentiation of these touch cells. In particular, unc-86 encodes a POU-type homeodomain protein needed for the production of the touch cells, while mec-3 encodes a LIM-t...

Journal: :Genetics 1984
D G Moerman R H Waterston

This paper describes a mutator system in the nematode Caenorhabditis elegans var. Bergerac for the gene unc-22. Of nine C. elegans and two C. briggsae strains tested only the Bergerac BO strain yielded mutant animals at a high frequency and the unc-22 IV gene is a preferred mutational target. The forward spontaneous mutation frequency at the unc-22 locus in Bergerac BO is about 1 X 10(-4), and ...

Journal: :Genetics 2006
Nicole K Charlie Michael A Schade Angela M Thomure Kenneth G Miller

C. elegans mutants lacking the dense-core vesicle priming protein UNC-31 (CAPS) share highly similar phenotypes with mutants lacking a neuronal G alpha(s) pathway, including strong paralysis despite exhibiting near normal levels of steady-state acetylcholine release as indicated by drug sensitivity assays. Our genetic analysis shows that UNC-31 and neuronal G alpha(s) are different parts of the...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2009
Edward Yeh Taizo Kawano Sharon Ng Richard Fetter Wesley Hung Ying Wang Mei Zhen

In a genetic screen for active zone defective mutants in Caenorhabditis elegans, we isolated a loss-of-function allele of unc-7, a gene encoding an innexin/pannexin family gap junction protein. Innexin UNC-7 regulates the size and distribution of active zones at C. elegans neuromuscular junctions. Loss-of-function mutations in another innexin, UNC-9, cause similar active zone defects as unc-7 m...

Journal: :Molecular biology of the cell 1999
M L Nonet A M Holgado F Brewer C J Serpe B A Norbeck J Holleran L Wei E Hartwieg E M Jorgensen A Alfonso

The unc-11 gene of Caenorhabditis elegans encodes multiple isoforms of a protein homologous to the mammalian brain-specific clathrin-adaptor protein AP180. The UNC-11 protein is expressed at high levels in the nervous system and at lower levels in other tissues. In neurons, UNC-11 is enriched at presynaptic terminals but is also present in cell bodies. unc-11 mutants are defective in two aspect...

2012
Rafael S. Demarco Eric C. Struckhoff Erik A. Lundquist

The mechanisms linking guidance receptors to cytoskeletal dynamics in the growth cone during axon extension remain mysterious. The Rho-family GTPases Rac and CDC-42 are key regulators of growth cone lamellipodia and filopodia formation, yet little is understood about how these molecules interact in growth cone outgrowth or how the activities of these molecules are regulated in distinct contexts...

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