Transport of the co-substrate UDPGA (UDP-glucuronic acid) into the lumen of the endoplasmic reticulum is an essential step in glucuronidation reactions due to the intraluminal location of the catalytic site of the enzyme UGT (UDP-glucuronosyltransferase). In the present study, we have characterized the function of several NSTs (nucleotide sugar transporters) and UGTs as potential carriers of UD...

Phase II metabolism is prominently governed by UDPglucuronosyltransferases (UGTs) in humans. These enzymes regulate the bioactivity of many drugs and endogenous small molecules in many organs, including the liver, a major site of regulation by the glucuronidation pathway. This study determined the expression of hepatic UGTs by targeted proteomics in 48 liver samples and by measuring the glucuro...

Carbinol [4,49-(hydroxymethylene)dibenzonitrile] is the main phase 1 metabolite of letrozole, a nonsteroidal aromatase inhibitor used for endocrine therapy in postmenopausal breast cancer. We elucidated the contribution of UDP-glucuronosyltransferase (UGT) isoforms on the glucuronidation of carbinol. Identification of UGT isoforms was performed using a panel of recombinant human UGT enzymes. Ki...

Although values of arch stiffness index (ASI) have been used to evaluate structure and injury susceptibility, investigations are limited regarding the influence ASI on biomechanical characteristics during gait termination, which involves a challenging balance transition from walking standing. This study aimed explore plantar pressure distribution lower extremity joint kinematic differences betw...

Purpose Citizen satisfaction with the government is a longstanding and continuous concern in public administration. However, past research did not investigate effect on context of mobile (m-government). The purpose this paper to evaluate how social benefits citizens using m-government affect their government. Design/methodology/approach Grounded uses gratifications theory (UGT), authors suggest...

Undisturbed ground temperature (UGT), thermal conductivity (TC) and heat capacity (HC) are essential parameters to design geothermal pumps underground energy storage systems, particularly borehole exchangers (BHE). However, field methods assess the state properties of subsurface costly time consuming. Moreover, HC is often not evaluated in situ but arbitrarily selected from literature consideri...

Carbinol [4,4'-(hydroxymethylene)dibenzonitrile] is the main phase 1 metabolite of letrozole, a nonsteroidal aromatase inhibitor used for endocrine therapy in postmenopausal breast cancer. We elucidated the contribution of UDP-glucuronosyltransferase (UGT) isoforms on the glucuronidation of carbinol. Identification of UGT isoforms was performed using a panel of recombinant human UGT enzymes. Ki...