In a genomewide anoikis suppression screen for metastasis genes, we previously identified the neurotrophic receptor tyrosine kinase TrkB. In mouse xenografts, activated TrkB caused highly invasive and metastatic tumors. Here, we describe that TrkB also induces a strong morphological transformation, resembling epithelial-mesenchymal transition (EMT). This required TrkB kinase activity, a functio...

A set of dynamical equations are derived for a slender tube of isolated magnetic ux generalizing a model due to Spruit. The tube is assumed to consist of eld lines which twist about the tube's axis at some rate q. The equations describe the evolution of the axis and the evolution of the twist. They include the interaction between twist and motions of the axis described as writhing. Through this...

We consider the Melvin Twist of AdS5×S5 under U(1)×U(1) isometry of the boundary S3 of the global AdS5 geometry and identify its field theory dual. We also study the thermodynamics of the Melvin deformed theory. Melvin twist, also known as the T-s-T transformation, is a powerful solution generating technique in supergravity and string theories [1–6]. The procedure relies on having a U(1)× U(1) ...

We give a general treatment of twist-three effects in two-photon reactions. We address the issue of the gauge invariance of the Compton amplitude in generalized Bjorken kinematics and relations of twist-three 'transverse' skewed parton distributions to twist-two ones and interaction dependent three-particle correlation functions. Finally, we discuss leading order evolution of twist-three functi...

Snail1 and Zeb1 are E-cadherin-transcriptional repressors induced during epithelialmesenchymal-transition (EMT). In this article we have analyzed the factors controlling Zeb1 expression during EMT. In NMuMG cells treated with TGF-β, Snail1 RNA and protein are induced one hour after addition of the cytokine preceeding Zeb1 up-regulation that requires six to eight hours. Zeb1 gene expression is c...

service Email alerting top right corner of the article Receive free email alerts when new articles cite this article-sign up in the box at the Background: The antiapoptotic and epithelial–mesenchymal transition activities of Twist have been implicated in the neoplastic transformation and the development of metastasis, respectively. Upregulation of Twist, described in several types of human canc...

Both TWIST and the endothelin-1 (ET-1)/endothelin A receptor (ETAR) signaling are important in osteosarcoma (OS) progression. In the present study, the interaction between TWIST and ET-1/ETAR signaling in OS cells was investigated, and the impact of the functional interaction on OS cell survival against chemotherapy agent-induced apoptosis was assessed. TWIST was overexpressed and knocked down ...

Problem statement: The objective of this study is to compare the methods for approximating the positions of twist fiber in yarn structures. Computer Aided Design (CAD) is applied using parametric equation, spline curve and NURBS curve. The ideal twist fiber and fiber migration are studied in 3 dimensions. Approach: The fiber positions in yarn structures were measured by trace fiber technique. T...

In wide kinematic regions the deeply inelastic structure functions can be described by their leading twist contributions within Quantum Chromodynamics (QCD). Higher twist corrections [1] emerge both in the region of large [2,3] and small values [4,5] of the Bjorken variable x. The leading twist sector, both for unpolarized and polarized deeply inelastic scattering, is well explored within pertu...