Sperm genomic integrity and ultrastructural features of ejaculated spermatozoa contributing to the assessment of gamete fertility potential in patients with asthenozoospermia are discussed. The proportion of TUNEL-positive cells was significantly higher in the semen of patients with low sperm motility (n=40; p<0.01) as compared to men with normal sperm motility (n=54). Sperm DNA fragmentation n...

Objective(s):In previous investigations, we have shown para-nonylphenol (p-NP) caused significant reduction of proliferation and differentiation of rat bone marrow mesenchymal stem cells (MSCs) in vitro. In this study, we first treat the rats with p-NP, then carried out the biochemical and morphological studies on MSCs. Materials and Methods: Proliferation property of cells was evaluated with t...

the p75 pan-neurotrophin receptor (p75ntr) plays a pivotal role in linking the immune system with the nervous system. p75ntr is required for the development of several characteristic features of allergic asthma. also p75ntr upregulated by reactive schwann cells after peripheral nerve injury. moreover p75ntr and rhoa play a critical role in the regulation of apoptosis. to determine whether the d...

objective(s): neuroprotective effect of creatine (cr) against β-amyloid (aβ) is reported in an in vitro study. this study investigated the effect of cr supplementation on β-amyloid toxicity in vivo. materials and methods: thirty two, male wistar rats were divided into 4 groups. during ten weeks of study, control group went through no surgical or dietary intervention. at the 4th week of study sh...

background: globozoospermia is a severe form of teratozoospermia (incidence < 0.1%) in infertile men that is characterized by round headed sperm and acrosomeless in semen. objective: to compare the semen parameters, protamine deficiency, and apoptosis in ejaculated spermatozoa between globozoospermic and normozoospermic men. materials and methods: thirty six semen samples were divided into two ...

AIM To investigate whether early apoptotic changes in spermatozoa can be significant markers for sperm quality. METHODS Two early apoptotic changes in the semen of 56 men were assessed using Annexin V (AN)/propidium iodide (PI) staining for phosphatidylserine externalization and JC-1 staining for mitochondrial membrane potential (MMP). The results were compared with conventional semen paramet...

It has previously been shown that acoustic overstimulation induces cell death and extensive cell loss in key structures of the central auditory pathway. A correlation between noise-induced apoptosis and cell loss was hypothesized for the cochlear nucleus and colliculus inferior. To determine the role of cell death in noise-induced cell loss in thalamic and cortical structures, the present mouse...

Abstract Osteosarcoma is the most common primary malignant bone tumor; main treatment method surgery and adjuvant chemotherapy, with a 5-year survival rate of less than 20% for metastatic patients. Schisandrin B abundant active ingredient found in fruit Schisandra chinensis (Turcz.) Baill., Schisandraceae, which has document properties such as liver protection, antioxidant, anti-inflammatory, a...

Bisphenol A (BPA) is used in the production of polycarbonate and epoxy resins. The weak estrogenic activity of BPA has been confirmed by both in vitro and in vivo assays. Retinal acetate has been reported to inhibit the adverse effects of BPA on male mice reproduction. All-trans-retinoic acid (ATRA) is a potent natural derivative of vitamin A and is reported to inhibit the estrogen-induced prol...