Tumor-derived exosomes (TEXs) are a class of extracellular vesicles which play an important role in the tumor microenvironment. These have multiple biological functions including promotion cancer progression and reduction anti-tumor immunity. Recently, interaction between TEXs immune cells great interest cell-based immunotherapy. Here, we review effects on survival T cell subsets, as well their...

Background/Aim: The tumor microenvironment plays an important role in progression. Tumor-associated macrophages (TAMs) have been reported to promote proliferation, invasion, metastasis, angiogenesis, and immunosuppression. Furthermore, angiogenesis has induce chemoresistance due the inefficient distribution of drugs cancer cells. However, impact TAMs on via colorectal (CRC) remains unclear. aim...

Background: Bax and Bcl-2 are the major members of Bcl-2 family whose play a key role in tumor progression or inhibition of intrinsic apoptotic pathway triggered by mitochondrial dysfunction. Therefore, the balance between pro- and anti-apoptotic members of this family can determine the cellular fate. Methods: In this study, the relative level of mRNA expression of Bax and Bcl-2 genes was deter...

background: odontogenic keratocyst (okc), also called keratocystic odontogenic tumor (kcot), is a developmental lesion which should be carefully monitored and it exhibits development mechanisms and biologic behaviors different from those of other more common lesions such as dentigerous and radicular cysts. cd10 antigen is a cell surface metalloendopeptidase, which inactivates various peptides t...

This study aimed to measure the incidence of tumor progression among patients that underwent endoscopic transsphenoidal surgery for pituitary adenomas, as well performance molecular and radiological factors are commonly associated with progression. Patients both adult pediatric populations adenomas who were treated first time in a single tertiary care center, between June 2006 December 2019, in...

The herpes virus entry mediator (HVEM) delivers a negative signal to T cells mainly through the B and lymphocyte attenuator (BTLA) molecule. Thus, HVEM/BTLA may represent novel immune checkpoint during an anti-tumor response. However, formal demonstration that HVEM can target for cancer immunotherapy is still lacking. Here, we first showed BTLA mRNA expression levels were associated with worse ...

Herein, we review the current findings of how a variety of accessory cells could participate in shaping the tumor microenvironment and supporting the mechanisms by which cancer cells undertake the epithelial-mesenchymal transition (EMT). EMT, a complex of phenotypic changes, promotes cancer cell invasion and creates resistance to chemotherapies. Among the accessory cells present in the EMT, imm...

Inflammation is a key factor in cancer promotion. Tumor-associated macrophages (TAMs), as part of the tumor microenvironment, are often associated with progression tumors and worse prognosis many cancers, namely on cervical cancer. This work exhaustively summarizes conclusions different studies published concerning TAMs function cancer, from vitro using cell lines to clinical perspective (histo...