Background: Nanomedicine has emerged as a powerful platform for applying nanotechnology in the prevention and treating many diseases. Objective: To investigate toxicity of designated anti-cancer drugs composed gold nanoparticles (GNPs), tumor necrosis factor-alpha (TNF-α), cysteine-Alanine-Leucine-Asparagine-Asparagine (CALNN) peptide on kidney liver parameters, using animals’ model. Methods: A...

background: there is no convenient cheap pragmatic experimental model for nonalcoholic fatty liver disease (nafld)/nonalcoholic steatohepatitis (nash). we aimed to create a pragmatic model of nafld/nash. methods: sprague-dawley rats were fed a high-fat, high sugar homemade diet ad libitum for seven weeks. the high-fat, high sugar diet included 59% of energy derived from fat, 30% from carbohydra...

To investigate the association of plasma levels of tumor necrosis factor-alpha (TNF-α) in patients with primary open angle glaucoma (POAG) patients as compared to non-glaucomatous controls. TNF-α concentrations were measured using sandwiched enzyme-linked immunosorbent assay (ELISA) in plasma samples from 39 POAG patients and 36 controls. The assay was performed in duplicate on an automated Che...

The tracheal epithelium prevents via its highly effective clearance mechanism the contamination of the lower airways by pathogens. This mechanism is driven by ciliary bearing cells which are not only in contact with the gas phase; in addition they are also influenced by inflammatory mediators. These mediators can alter the protective function of the epithelium. Since the pro-inflammatoric cytok...

background: infertility is a problem concerning 10-15% of the individuals in the fertile period. this study investigated effects of proinflammatory factors as well as lipid hydroperoxides (lpo) levels upon in vitro fertilization (ivf) success. materials and methods: in this prospective, non-randomized, controlled clinical study, sera obtained from 26 fertile (group-1), 26 infertile women before...

background: endometrial secretion analysis is a non-invasive and promising method in evaluation of endometrial receptivity. objective: the aim of the present study was to assess the relationship between the success rate of ivf procedures and some endometrial secretion cytokines, including interleukin-1β (il-1β), tumor necrosis factor (tnf-α), interferon gamma-induced protein 10 (ip-10), and mon...

The JAR choriocarcinoma cell line share many of the characteristics of early placental trophoblast cells including the invasion properties. Matrix metallo-proteinases (MMPs), the main actors of matrix proteolysis, are involved in normal invasion as well as in the invasive character of tumor cells and the metastase formation. Tumor necrosis factor-α (TNF-α) is present in the placental environmen...

Triple Negative Breast Cancer (TNBC) immunotherapy has recently shown promising approach. However, some TNBC patients presented with resistance. One of the reasons was attributed to excessive release cytokines at tumor microenvironment (TME) such as Tumor necrosis factor alpha (TNF-α) and Interleukin-10 (IL-10). Fine regulation these cytokines’ levels via non-coding RNAs (ncRNAs) might alleviat...

Tumor necrosis factor-alpha (TNF-α) is a pleiotropic inflammatory cytokine produced mainly by activated macrophages, lymphocytes and other cell types. Two distinct forms of TNF-α have been identified: soluble TNF-α (sTNF-α) and transmembrane TNF-α (mTNF-α). mTNF-α, which is the precursor of sTNF-α, can be cleaved by the TNF-α converting enzyme (TACE) and is released as sTNF-α. sTNF-α binds prim...