نتایج جستجو برای: tumor inhibition
تعداد نتایج: 715754 فیلتر نتایج به سال:
Pharmacological focal adhesion kinase (FAK) inhibition prevents tumor growth and metastasis, via actions on both tumor and stromal cells. In this paper, we show that vascular endothelial cadherin (VEC) tyrosine (Y) 658 is a target of FAK in tumor-associated endothelial cells (ECs). Conditional kinase-dead FAK knockin within ECs inhibited recombinant vascular endothelial growth factor (VEGF-A) a...
introduction: angiogenesis, the process of new blood vessel formation from pre-existing vessels, has important physiological roles in embryonic development, female reproduction cycle, and wound healing. it is also crucial for pathological processes in several diseases especially tumor growth and metastasis. thereby, inhibition of angiogenesis as an addition to the conventional therapies such as...
PURPOSE The oncogenic PI3K/Akt/mTOR pathway is an attractive therapeutic target in cancer. However, it is unknown whether the pathway blockade required for tumor growth inhibition is clinically achievable. Therefore, we conducted pharmacodynamic studies with GDC-0068, an ATP competitive, selective Akt1/2/3 inhibitor, in preclinical models and in patients treated with this compound. EXPERIMENT...
The objective of this study is to investigate the anti-tumor effect of Ginkgo biloba exocarp extracts (GBEE) on B16 melanoma bearing mice and its related molecular mechanisms. The B16-F10 melanoma solid tumor model was established in C57BL/6J mice. The tumor-bearing mice were treated with GBEE (50, 100, 200 mg/kg), taking cis-Dichlorodiamineplatinum (Ⅱ) (DDP, 3 mg/kg) as pos...
Introduction Tumor-associated macrophages may act to either limit or promote tumor growth, yet the molecular basis for path is poorly characterized. Methods We use a larval Drosophila model that expresses dominant-active version of Ras-oncogene (Ras V12 ) study dysplastic growth during early progression. performed single-cell RNA-sequencing macrophage-like hemocytes characterize these cells in ...
Immunogenic cell death (ICD) is accompanied by changes in the composition of surface and release soluble mediators. Such signals operate on dendritic cells to stimulate presentation tumor antigens T cells. We recently found that low expression glucose-6-phosphate dehydrogenase (G6PD), a cytoplasmic enzyme involved pentose phosphate pathway, correlates with active anti-tumor immunity. G6PD maint...
We show that integrin-linked kinase (ILK) stimulates the expression of VEGF by stimulating HIF-1alpha protein expression in a PKB/Akt- and mTOR/FRAP-dependent manner. In human prostate cancer cells, knockdown of ILK expression with siRNA, or inhibition of ILK activity, results in significant inhibition of HIF-1alpha and VEGF expression. In endothelial cells, VEGF stimulates ILK activity, and in...
Introduction: Cholangiocarcinomas (CCA) are rare, aggressive tumors often diagnosed in advanced stages with limited evidence guiding therapy on progression. Case Report: We report a case of CCA rapid and aberrant progression, refractory to multiple lines therapy, that resulted severe hepatic dysfunction secondary tumor burden BRAF V600E mutation high proportion score (TPS) 99%. To our knowledge...
Histone deacetylases (HDAC) modify the architecture of chromatin, leading to decreased gene expression, an effect that is reversed by HDAC inhibition. The balance between deacetylation and acetylation is central to many biological events including the regulation of cell proliferation and cancer but also the differentiation of immune T cells. The effects of HDAC inhibition on the interaction bet...
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