Photodynamic therapy (PDT) can lead to the creation of heterogeneous, response-limiting hypoxia during illumination, which may be controlled in part through illumination fluence rate. In the present report we consider (1) regional differences in hypoxia, vascular response, and cell kill as a function of tumor depth and (2) the role of fluence rate as a mediator of depth-dependent regional intra...

BACKGROUND Oral (mobile) tongue squamous cell carcinoma (SCC) is characterized by a highly variable prognosis in early-stage disease (T1/T2 N0M0). The ability to classify early oral tongue SCCs into low-risk and high-risk categories would represent a major advancement in their management. METHODS Depth of invasion, tumor budding, histologic risk-assessment score (HRS), and cancer-associated f...

Purpose: To compare the accuracy of detecting tumor location and size in the prostate using both manual palpation and ultrasound elastography (UE). Methods: Tumors in the prostate were simulated using both synthetic and ex vivo tissue phantoms. 25 participants were asked to provide the presence, size and depth of these simulated lesions using manual palpation and UE. Ultrasound images were capt...

PURPOSE The aim of the present study was to assess the association between the pre-operative plasma fibrinogen level and the adjacent organ involvement in advanced gastric cancer. MATERIALS AND METHODS A total of 923 pre-operative plasma samples were obtained from 923 patients diagnosed clinically as having advanced gastric cancer, and fibrinogen levels were measured by immunoassay. Associati...

Objectives B cell-mediated immunity can be associated with favorable clinical outcomes in cancer patients. However, the mechanism and features of anti-tumor immune responses are not well understood. In particular, how cells expressing tumor-specific antibodies distributed (in tumor vs. circulation) has been defined. Methods We performed an in-depth analysis cell antibody repertoires derived fro...

Introduction In order to treat uveal Melanoma , first, radioactive seeds are laid on a silicone- made substance which is called Silastic after that they are inserted in the plaque, and finally, this plaque containing silicone-made substance is stitched to the sclera surface. The dose gradient within the tumor and healthy tissues can be varied due to changing the Silastic thickness between scler...

BACKGROUND The prognosis of gastric cancer patients is difficult to predict because of defects in establishing the surgical-pathological features. Cancer-associated fibroblasts (CAFs) have been found to play prominent role in promoting tumor growth, invasion and metastasis. Thus raises the hypothesis that the extent of CAFs prevalence may help to establish the prognosis of gastric cancer patien...

introduction: in this paper, by complete definition of human eye containing the various parts and their materials, the difference between this model and a homogeneous water phantom are compared for two ophthalmic plaques using 125i and 103pd. material and methods: the simulation of the two phantoms were performed in the mcnp-4c code and by using the geometry of a three-dimensional eye, differen...

introduction in order to treat uveal melanoma , first, radioactive seeds are laid on a silicone- made substance which is called silastic after that they are inserted in the plaque, and finally, this plaque containing silicone-made substance is stitched to the sclera surface. the dose gradient within the tumor and healthy tissues can be varied due to changing the silastic thickness between scler...