BACKGROUND Dendritic cell (DC)-based tumor vaccine is an attractive modality for the treatment of colon cancer because it has been recurred and produced few side effects in patients. Secretory glycoprotein 90K has been found at elevated level in various cancer tissues and sera. We investigated to establish a more effective DC vaccine for the treatment of colon cancer in which the levels of 90K ...

We have evaluated whether the addition of a foreign helper protein, keyhole limpet hemocyanin (KLH), can augment the efficacy of tumor lysate-pulsed dendritic cells and peptide-pulsed DC immunizations in vivo. Besides being used as a "surrogate antigen" in approaches to measure immunological response in cancer patients, KLH is also an immunogenic carrier protein to elicit T-cell help. Using the...

Novel strategies for the therapy of recurrent ovarian cancer are warranted. We report a study of a combinatorial approach encompassing dendritic cell (DC)-based autologous whole tumor vaccination and anti-angiogenesis therapy, followed by the adoptive transfer of autologous vaccine-primed CD3/CD28-co-stimulated lymphocytes. Recurrent ovarian cancer patients for whom tumor lysate was available f...

Induction of mucosal immune responses against Porphyromonas gingivalis within the oral cavity of dogs was studied by immunizing with pH-sensitive fusogenic polymer (MGluPG)-modified liposome-associated cell lysate. Dogs immunized with P. gingivalis cell lysate-containing MGluPG-modified liposomes by intraocular (eye drop) route displayed significant levels of P. gingivalis cell lysate-specific ...

background: toxoplasma gondii is an obligatory intracellular protozoan parasite on which studies are pending regarding production of vaccine. to date, the production of human vaccine has not been successful where approximately one third of the world’s population is thought to be infected with t. gondii. objectives: the present study was designed to compare the electrophoretic patterns of t. gon...

systemic amyloidosis and testicular interstitial tumor are rare conditions in birds and this is the first report in iran. a male zebra finch was presented because of white diarrhea, anorexia, loss of weight and lethargy. at necropsy, the small intestine was edematous and congested. the spleen appeared pale. the liver was large, firm and brown. one testis was cystic and neoplastic and the remain...

introduction: granular cell tumors (gcts) are rare and mostly benign soft tissue tumors. though they have been reported in all parts of body, they are generally located in the head and neck region, especially on the tongue. some malign forms exist, but these have been rarely reported. granular cell tumors have a neural origin and, in immunohistochemical evaluations, they express s-100 and neuro...