Despite a Mycobacterium tuberculosis control programme and anti-tuberculosis drugs, drug-resistant tuberculosis (DR-TB) is one of the most serious public health issues worldwide. Rapid laboratory diagnosis of M. tuberculosis is needed for the diagnosis of multidrug-resistant (MDR) TB and to find the optimal treatment protocol. The purpose of this study was to detect resistance to rifampicin in ...

Background: At present, despite the generally favorable pathomorphosis of tuberculosis (TB), a number factors that have negative impact on epidemiological situation, clinical manifestations and treatment outcomes remain. Objective: To determine role aggravating in development destructive pulmonary tuberculosis. Material methods: A prospective cohort study was conducted. The patients who were ad...

objectives in order to increase the classification accuracy of airs, this study introduces a new hybrid system that incorporates a support vector machine into airs for diagnosing tuberculosis. background tuberculosis (tb) is a major global health problem, which has been ranked as the second leading cause of death from an infectious disease worldwide. diagnosis based on cultured specimens is the...

BACKGROUND An IFN-γ response to M. tuberculosis-specific antigens is an effective biomarker for M. tuberculosis infection but it cannot discriminate between latent TB infection and active TB disease. Combining a number of cytokine/chemokine responses to M. tuberculosis antigens may enable differentiation of latent TB from active disease. METHODS Asymptomatic recently-exposed individuals (spou...

Tuberculosis (TB), caused by Mycobacterium tuberculosis is an infectious deadly disease and the treatment of which is one of the most severe challenges at the global level. Currently more than 20 chemical medications are described for the treatment of TB. Regardless of availability of several drugs to treat TB, the causative agent, M. tuberculosis is nowadays getting resistant toward the conven...

  Introduction: Development of effective immunodiagnostic methods for detection of Mycobacterium tuberculosis infection is crucial. Serodiagnostic methods, based on antibody response to specific antigens could provide promising approaches for rapid, economical and easy to perform diagnostic tests which are crucial for tuberculosis (TB) control. In this study, the level of IgG antibody responses...

BACKGROUND The immunologic environment during HIV/M. tuberculosis co-infection is characterized by cytokine and chemokine irregularities that have been shown to increase immune activation, viral replication, and T cell dysfunction. METHODS We analysed ex vivo plasma samples from 17 HIV negative and 16 HIV pulmonary tuberculosis co infected cases using Luminex assay to see impact of HIV co-inf...

AIM To determine association between tuberculosis (TB) related stigma and delay in seeking a treatment after the onset of symptoms associated with tuberculosis. METHODS This prospective study was carried out in the "Podhrastovi" University Clinic of Lung Diseases and Tuberculosis and Health facilities for lung diseases and tuberculosis in the Sarajevo area. The sample consisted of 300 tubercu...

Background & Aims: Tuberculosis is one of the most important causes of mortality in the world and if it is not treated, 50 – 65% of patients would die in five years. Chest X-ray has an important role in the diagnosis of TB and early diagnosis and treatment prevent tuberculosis transmission. In this study we evaluated radiologic manifestations of patients with smear positive pulmonary tubercu...