Tuberculosis (TB), caused by the bacteria Mycobacterium tuberculosis, is notorious for its lethality to humans. Despite technological advances, the tubercle bacillus continues to threaten humans. According to the World Health Organization's 2011 global report on TB, 8.8 million cases of TB were reported in 2010, with a loss of 1.7 million human lives. As drug-susceptible TB requires long-term t...

Tumor necrosis factor α antagonist therapies represent an increased risk of reactivation of tuberculosis. We report two cases of life-threatening disseminated tuberculosis in patients undergoing treatment with infliximab for Crohn's disease including one case of a patient with cerebral tuberculomas. We discuss the implication of tumor necrosis factor α in the genesis of tuberculosis infection a...

Objective(s) Isoniazid (INH) is one of the main first line drugs used in treatment of tuberculosis and development of resistance against this compound can result in serious problems in treatment procedures. Resistance to INH is mediated mainly by mutation in KatG gene that is coded for the catalase enzyme. The proportional method for detection of INH-resistance is time consuming due to the slo...

Introduction : One of the top 10 causes death worldwide is tuberculosis (TB). An estimated million new cases TB, including 1.2 in children, were reported 2019. Due to symptoms pediatric (TB) being similar those other juvenile illnesses and difficulty obtaining lung samples due children's propensity swallow sputum, diagnosing TB challenging. Methods This systematic review's objective was find re...

Tumor necrosis factor-α inhibitors are now considered as standard therapy for patients with severe inflammatory bowel disease who do not respond to corticosteroids, but they carry a definite risk of reactivation of tuberculosis. We present a case in which a patient with inflammatory bowel disease developed a de novo tuberculosis infection after the start of anti-tumor necrosis factor-α treatmen...

Tuberculosis (TB) is a major cause of childhood morbidity and mortality worldwide. The aim of this review is to describe the management of the child with TB and latent tuberculosis infection (LTBI). To develop this article, a working group reviewed relevant epidemiological and other scientific studies and established practices in conducting LBTI and TB in children. The article describes how to ...

CONTEXT Concern about transmission of Mycobacterium tuberculosis on college campuses has prompted some schools to institute tuberculin skin test screening of students, but this screening has never been evaluated. OBJECTIVE To describe tuberculin skin test screening practices and results of screening in colleges and universities in the United States. DESIGN AND SETTING Self-administered mail...

Considerable efforts and concurrent studies have been made to substantiate the control of tuberculosis (TB). The was not achieved significantly, as stigma is one significant barriers controlling tuberculosis. It hampers TB treatment’s determined targeted completion. However, despite countless measures improve therapy completion, non-adherence remains a global issue. This systematic review aimed...

OBJECTIVE Between November 1994 and April 1995, more than 3300 students in 49 schools in two counties in New York were potentially exposed to five school bus drivers with tuberculosis. This investigation was carried out to determine the extent of transmission of Mycobacterium tuberculosis among students. METHODS Components of the epidemiologic investigation included tuberculin skin-test scree...