focus or foci to heal, and secondly, to prevent its spread and tuberculin aids in both these aims The essentials for success are laid down as individualization, size of dose, method of increase and interval" together with a full appreciation of the underlying disease conditions by the physician. The author pertinently remarks that the man who determines to try tuberculin should not do so to tes...

1. Mononuclear exudative cells, obtained from tuberculous guinea pigs by the intrapleural injection of parowax, exhibited characteristic sensitivity to the toxic action of tuberculin when tested in tissue culture. 2. Experiments with these cells, practically free of body fluids, show conclusively that sensitivity to tuberculin is an inherent characteristic of mesenchymal cells from tuberculous ...

The T cell response to a mixture of eight peptides derived from sequences of the Mycobacterium tuberculosis 16-, 19- and 38-kD antigens (MTBmix-8) has been studied. The peptides were selected on the basis of complementary binding to nine HLA-DR molecules (HLA-DR1 to DR9). MTBmix-8 at 6.25 and 50 micrograms/ml gave rise to significant stimulation (P < 0.05) of peripheral blood mononuclear cells ...

A naturally occurring outbreak of Mycobacterium bovis infection in captive wild elk (wapiti) in Montana was confirmed by mycobacteriologic examination. Twenty-eight of 143 elk responded to M. bovis purified protein derivative (PPD) tuberculin injected intradermally in the cervical region (SCT). The results of comparative cervical tuberculin skin tests conducted within 9 days of SCT revealed gre...