The purpose of this perspective is to communicate several fundamental biologic features of TSE infections that may not be apparent to scientists who do not isolate and characterize infectious particles, or analyze different TSE agent-strains. At high multiplicity, TSE agents can induce pathological misfolding of host PrP into PrP-res amyloid. However, infection is not required for this conversi...

PURPOSE To develop a mouse model of neurotrophic keratopathy by approaching the trigeminal nerve through the brain and to evaluate changes in corneal cell apoptosis and proliferation. METHODS Six- to 8-week-old male C57BL/6 mice underwent trigeminal stereotactic electrolysis (TSE) to destroy the ophthalmic branch of the trigeminal nerve. Clinical follow-up using biomicroscopy of the cornea wa...

Objective To compare the T1-weighted spectral presaturation with inversion-recovery sequences (T1 SPIR) with T2-weighted turbo spin-echo sequences (T2 TSE) on 3T magnetic resonance arthrography (MRA) in the evaluation of the subscapularis (SSC) tendon tear with arthroscopic findings as the reference standard. Materials and Methods This retrospective study included 120 consecutive patients who...

In the light of the background report presented in section II, the Scientific Steering Committee considers that studies in non-human primates should make an important and unique contribution to several experiments aimed at quantifying TSE associated risks in humans. They will also contribute important and valuable information to the pre-clinical development of new therapeutic strategies and val...

background: while young men are at higher risk of developing testicular cancer (tc), testicular-self examination (tse) is an easy, cost effectiveness method to early detection of this disease. the aim of the study was to investigate medical sciences student`s awareness, attitude and self-efficacy about tc and tse. methods: this cross-sectional study was carried out among full time young student...

The transition-state ensemble (TSE) is the set of protein conformations with an equal probability to fold or unfold. Its characterization is crucial for an understanding of the folding process. We determined the TSE of the src-SH3 domain protein by using extensive molecular dynamics simulations of the Go model and computing the folding probability of a generated set of TSE candidate conformatio...

The folding pathway of common-type acyl phosphatase (ctAcP) is characterized using psi-analysis, which identifies specific chain-chain contacts using bi-histidine (biHis) metal-ion binding sites. In the transition state ensemble (TSE), the majority of the protein is structured with a near-native topology, only lacking one beta-strand and an alpha-helix. psi-Values are zero or unity for all site...

Introduction: Multi slice T2w-TSE and FLAIR-TSE sequences are two of the most important techniques in neuro-radiology. The problem of partial volume effects and inherent CSF-inflow artifacts in FLAIR can be resolved by using a non-selective 3D-TSE acquisition technique with advanced refocusing pulse angle sweep [1]. A disadvantage of 3D TSE sequences with isotropic voxel size smaller than 1mm i...

Putative transition-state ensemble (TSE) conformations of src SH3 were identified by monitoring the deviation from the experimental phi values along molecular dynamics (MD) simulations of unfolding. Sixty MD trajectories (for a total of about 7 micros) were then started from the putative TSE. About one-half of the 60 runs reached the folded state while unfolding was observed in the remaining ha...