Multiple cardiac rhabdomyomas are frequently associated with tuberous sclerosis (TSC). However, splenic involvement in TSC is very rare. Histiocytoid cells in the spleen have been previously reported in only seven neonates and one fetus. We report an unusual case of multiple cardiac rhabdomyomas in a stillborn fetus with TSC who had clusters of histiocytoid cells in the spleen. These large cell...

CONTEXT We have previously shown that serum VEGF-D is elevated at baseline, correlates with kidney angiomyolipoma size at baseline and 12 months, and decreases with sirolimus treatment in adults with tuberous sclerosis complex (TSC). To further investigate the utility of serum VEGF-D for longer term monitoring of TSC kidney disease, we present VEGF-D level results with 24 month follow-up. OBJ...

Most of the missense mutations that have been described in the human SLC12A3 gene encoding the thiazide-sensitive Na(+)-Cl(-) cotransporter (TSC, NCC, or NCCT), as the cause of Gitelman disease, block TSC function by interfering with normal protein processing and glycosylation. However, some mutations exhibit considerable activity. To investigate the pathogenesis of Gitelman disease mediated by...

Does trait self-control (TSC) predict affective well-being and life satisfaction--positively, negatively, or not? We conducted three studies (Study 1: N = 414, 64% female, Mage = 35.0 years; Study 2: N = 208, 66% female, Mage = 25.24 years; Study 3: N = 234, 61% female, Mage = 34.53 years). The key predictor was TSC, with affective well-being and life satisfaction ratings as key outcomes. Poten...

Due to the rapid technological progress, the consumption of electric energy increases continuously. But the transmission systems are not extended to the same extent because building of new lines is difficult for environmental as well as political reasons. Hence, the systems are driven closer to their limits resulting in congestions and critical situations endangering the system security. Power ...

BACKGROUND AND OBJECTIVES Our objective was to identify differentially expressed genes involved in the pathogenesis of glioblastoma multiforme (GBM). METHODS Screening of arrayed human fetal brain and human postnatal brain cDNA libraries was performed by differential hybridization with glioblastoma multiforme and human normal brain cDNAs. RESULTS Repeated differential hybridization of more ...

Prediction of nuclear products both for metaldeuterium systems and metal protium systems is made on the basic physics of cold fusion by the TSC (tetrahedral symmetric condensate) theory. This paper focuses on final state nuclear reactions of intermediate compound states as 8Be* of 4D/TSC fusion and 4Li* of 4H/TSC WS fusion. Prediction of final products is made by the nucleon-halo model of the h...

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by hamartomatous involvement of multiple organs such as the skin, central nervous system, kidneys, lungs, and heart. A linkage has been found with a locus on the long arm of chromosome 9 (9q34) and with a locus on the short arm of chromosome 16 (16p13). TSC has a birth incidence of 1/6000. Children with TSC are alm...

CELL LINEAGE CHOICE DURING DIFFERENTIATION OF TROPHOBLAST STEMCELLS (TSC) IS DEPENDENT ON OXYGEN LEVELS, AND MEDIATED BY STRESSENZYME PATHWAYS AND MITOCHONDRIAL FUNCTIONbySICHANG ZHOUDecember 2011Advisor: Dr. Daniel A. RappoleeMajor: Physiology, Concentration in Reproductive SciencesDegree: Doctor of PhilosophyIn general, stress is defined as a noxious fa...

Tuberous sclerosis complex (TSC) is associated with neurodevelopmental abnormalities, including defects in neuronal migration. However, the alterations in cell signaling mechanisms critical for migration and final positioning of neurons in TSC remain unclear. Our detailed cellular analyses reveal that reduced Tsc2 in newborn neurons causes abnormalities in leading processes of migrating neurons...