Retinoic acid (RA) induces cell cycle arrest and differentiation of human neuroblastoma (NB) cells. Typically, NB cells differentiate along the neuronal lineage, but quiescent, "flat" cell types frequently have been described after treatment with differentiating agents. Two indistinguishable subclones of the cell line SK-N-SH, SK-N-SH-N (SH-N) and SK-N-SH-F (SH-F), display dramatically differen...

The antigenic relationship between human neuronal and lymphocyte cell surface antigens has been analyzed using heteroantisera raised against human peripheral blood mononuclear cells (PBMC). The specificities of the crossreactive antigens were examined by immunoprecipitation of 125I-labeled SK-N-SH cultured neuronal cells using rabbit anti-PBMC (RAPBMC) sera and compared to known specificities u...

Abstract A small particle telescope based on two silicon detectors was flown on three NASA Shuttle-to-MIR missions and on the Russian orbital station MIR behind a shielding of about 10-20 g/cm2 in low Earth orbits at 51.6 degree inclination during 1996/98. The instrument was designed to measure count rates and dose rates as well as energy deposit spectra (in silicon) of the radiation inside the...

The number of SH-groups of the soluble proteins (Prot-SH) of 12 different types of animal tumors and of cultivated chicken fibroblasts increases with decreasing doubling time (id) ■ Between Prot-SH and id an inverse association was found with a significance level of 99.5%. After 30 min incubation in vitro, 4-hydroxypentenal (HPE) reacts with different amounts of the Prot-SH of the investigated ...

In recent years, the condition of subclinical hypercortisolism (SH) has become a topic of growing interest. This is due to the fact that SH prevalence is not negligible (0.8-2% in the general population) and that, although asymptomatic, this subtle cortisol excess is not harmless, being associated with an increased risk of complications, in particular of osteoporosis and fragility fractures. As...

Aim: Mast cells are versatile innate immune cells and are reported to promote vascular inflammation and neointimal lesion formation, thereby contributing to the development of vascular stenosis and atherosclerosis. However, it is not clear whether mast cells also regulate vascular matrix remodelling in established neointima. This study addressed the hypothesis that perivascular mast cells regul...

The spatio-temporal expression of Shaker (Sh) potassium channels (Kch) in the developing and adult nervous system of Drosophila has been studied at the molecular and histological level using specific antisera. Sh Kch are distributed in most regions of the nervous system, but their expression is restricted to only certain populations of cells. Sh Kch have been found in the following three locati...

In this paper, we focus on the objective prediction of two of the foreground perceptual quality elements of the Diagnostic Acceptability Measure (DAM) that of SB and SF and show that they are correlated with statistical characteristics of features extracted from a physiologically motivated cochlear model response. The work complements earlier work where two other DAM quality elements, SH and SL...

We consider the formation of the recently discovered “hot Jupiter” planet orbiting the primary component of the triple star system HD188753. Although the current outer orbit of the triple is too tight for a Jupiter-like planet to have formed and migrated to its current location, the binary may have been much wider in the past. We assume here that the planetary system formed in an open star clus...