نتایج جستجو برای: trpv3
تعداد نتایج: 245 فیلتر نتایج به سال:
Depending on their primary structure, the 28 mammalian transient receptor potential (TRP) cation channels identified so far can be sorted into 6 subfamilies: TRPC ("Canonical"), TRPV ("Vanilloid"), TRPM ("Melastatin"), TRPP ("Polycystin"), TRPML ("Mucolipin"), and TRPA ("Ankyrin"). The TRPV subfamily (vanilloid receptors) comprises channels critically involved in nociception and thermosensing (...
Transient receptor potential melastatin-2 (TRPM2) channel critical for monitoring internal body temperature is implicated in the pathological processes such as neurodegeneration. However, lacking selective and potent TRPM2 inhibitors impedes investigation and validation of the channel as a drug target. To discover novel and selective TRPM2 inhibitors, a series of adenosine 5'-diphosphoribose an...
Background: Scalp psoriatic itch is a prevalent yet understudied condition with numerous associated treatment challenges. Objective: The current study aims to enhance our understanding of scalp pathophysiology in order guide management and identify novel targets. Methods: Immunohistochemical analysis known neuroimmune mediators pruritus was conducted using biopsies from 27 patients psoriasis. P...
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