Lipid analogues carrying three nitrilotriacetic acid (tris-NTA) head groups were developed for the selective targeting of His-tagged proteins into liquid ordered (lo ) or liquid disordered (ld ) lipid phases. Strong partitioning into the lo phase of His-tagged proteins bound to tris-NTA conjugated to saturated alkyl chains (tris-NTA DODA) was achieved, while tris-NTA conjugated to an unsaturate...

Diagnosis of scabies in young children can be challenging since the morphology and distribution of skin lesions may differ from adults. Therefore, clinicians should keep scabies in mind in their differential diagnosis in a child who presents with severe pruritic, polymorphic skin lesions. Regarding the treatment of scabies, the reported clinical experience with gamma benzene hexachloride (linda...

While it has been generally accepted that genotoxic carcinogens have no dose threshold for their carcinogenic potential, there is increasing evidence that very low doses in fact are incapable of inducing tumours or preneoplastic lesions. Thus not only so-called epigenetic 'non-genotoxic' compounds like phenobarbital and benzene hexachloride, but also unequivocally genotoxic carcinogens like the...

PURPOSE To compare the efficacy of single-dose gadolinium with magnetization transfer contrast (MTC) with that of triple-dose gadolinium in detecting enhancing multiple sclerosis lesions. METHODS Twenty-one patients with multiple sclerosis were examined with MR imaging first with 0.1 mmol/kg gadolinium (single dose) and then, after 24 to 72 hours, with 0.3 mmol/kg gadolinium (triple dose). T2...

OBJECTIVE To identify medications and other potential risk factors, in addition to renal dysfunction, for developing gadolinium-induced nephrogenic systemic fibrosis (NSF). DATA SOURCES Information was obtained from PubMed, International Pharmaceutical Abstracts, Iowa Drug Information Service, and Google Scholar, using the unlimited search terms nephrogenic systemic fibrosis, NSF, nephrogenic...

The current study aims to explore how the gadolinium (Gd)-based contrast agent (GBCA) Omniscan® enhanced cell viability of murine fibroblasts. The results of scanning electron microscopy showed that Omniscan® can precipitate in cell culture media and deposit on cell membranes. Energy-dispersive X-ray analysis and Fourier-transform infrared spectroscopy demonstrated the presence of Gd and phosph...

Two phosphonium-derived ionic liquids: trihexyltetradecylphosphonium bis(2-ethylhexyl)phosphate (IL1) and tricyanomethanide (IL2) were used as additives in lithium complex- (G1) anhydrous calcium-based (G2) greases at 5 wt%. Friction torque wear tests performed using a modified four-ball machine for testing rolling bearings order to determine the friction reducing properties of these grease sam...

The corrosion behavior of Cu in antifreeze solutions containing 2,4,6-Tris(5-carboxypentylamino)1,3,5-triazine, 2,4,6-Tris(11-carboxyundecylamino)1,3,5-triazine, 1-Aminomethyl(N′,N′-di(2-hydroxyethyl)tolutriazole, or 1-Aminomethyl(N′,N′-di(2-hydroxyethyl)benzotriazole as inhibitors were examined by immersion test for 3 weeks well potentiodynamic polarization tests before and after test. rate wa...