نتایج جستجو برای: triptolide

تعداد نتایج: 676  

2015
Qian Zhao Yu Ding Zhangshuang Deng On-Yi Lee Peng Gao Pin Chen Rebecca J. Rose Hong Zhao Zhehao Zhang Xin-Pei Tao Albert J. R. Heck Richard Kao Dan Yang

Morningside Laboratory for Chemical B University of Hong Kong, Hong Kong, China School of Life Sciences, Fudan University, S Hubei Key Laboratory of Natural Product Biological and Pharmaceutical Sciences, C China Department of Microbiology, The Universit Bijvoet Center for Biomolecular Research Sciences, Utrecht University, Netherlands Pr Department of Chemistry, The Chinese Univ † Electronic s...

Journal: :Indian journal of entomology 2022

Five blocks of farmer’s sugarcane fields were selected in district Jalandhar, Punjab during December 2016 to February 2017. These treated with 2% zinc phosphide (ZnP), ZnP+ 0.005% bromadiolone (Br), 0.25% triptolide (Tr) and Br+ Tr at cane maturation stage; 5th block was kept as untreated control. The post census % re-buildup rodents after 30 45 days treatment cut canes (%) significantly less r...

Journal: :Molecular cancer therapeutics 2003
John M Fidler Ke Li Cathie Chung Ke Wei Jessica A Ross Mingxing Gao Glenn D Rosen

Treatment of solid tumors with combinations of chemotherapeutic agents has not led to significant increases in long-term survival. Recent studies support a role for inhibitors of checkpoint arrest as a means to enhance the cytotoxicity of chemotherapy. We have shown previously that triptolide (PG490), an oxygenated diterpene derived from a Chinese medicinal plant, induces apoptosis in cultured ...

Journal: :Physiological genomics 2004
Laszlo T Vaszar Toshihiko Nishimura John D Storey Guohua Zhao Daoming Qiu John L Faul Ronald G Pearl Peter N Kao

Pneumonectomized rats injected with the alkaloid toxin, monocrotaline, develop progressive neointimal pulmonary vascular obliteration and pulmonary hypertension resulting in right ventricular failure and death. The antiproliferative immunosuppressant, triptolide, attenuates neointimal formation and pulmonary hypertension in this disease model (Faul JL, Nishimura T, Berry GJ, Benson GV, Pearl RG...

Journal: :Journal of cell science 2013
Claudia Villicaña Grisel Cruz Mario Zurita

Transcription factor IIH (TFIIH) participates in transcription, nucleotide excision repair and the control of the cell cycle. In the present study, we demonstrate that the Dmp52 subunit of TFIIH in Drosophila physically interacts with the fly p53 homologue, Dp53. The depletion of Dmp52 in the wing disc generates chromosome fragility, increases apoptosis and produces wings with a reduced number ...

2012
Chung-Jen Chiang Jai-Sing Yang Yun-Peng Chao Li-Jen Lin Wen-Wen Huang Jing-Gung Chung Shu-Fen Peng Chi-Cheng Lu Minoru Tsuzuki

Tripterygium wilfordii Hook. f. is a traditional Chinese herb (Murphy, 2006; Qiu et al., 2003). The extract of Tripterygium wilfordii Hook. f. has been widely applied to the treatment of immune-related diseases, such as rheumatoid arthritis (RA), nephritis, and systemic lupus erythematosus (SLE) (Chang et al., 1999; Wang et al., 2000). Extracts of Tripterygium wilfordii Hook. f. have been shown...

2012
Dan Wang Mitchell L. Wise Feng Li Moul Dey

Phytochemicals are a rich source of chemoprevention agents but their effects on modulating the Wnt/β-catenin signaling pathway have remained largely uninvestigated. Aberrantly activated Wnt signaling can result in the abnormal stabilization of β-catenin, a key causative step in a broad spectrum of cancers. Here we report the modulation of lithium chloride-activated canonical Wnt/β-catenin signa...

Journal: :Molecules 2013
Cong Zhang Conghui Gu Fan Peng Wei Liu Jiangling Wan Huibi Xu Christopher Waikei Lam Xiangliang Yang

Triptolide (TP) often causes adverse reactions in the gastrointestinal tract when it is administered orally. This study aimed to prepare and optimize triptolide-loaded solid lipid nanoparticles (TP-SLN) with reduced gastric irritation. The microemulsion technique was used to formulate TP-SLN employing a five-level central composite design (CCD) that was developed for exploring the optimum level...

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