Triple helix-forming oligonucleotides covalently linked to psoralen can be specifically cross-linked to both strands of DNA at the triplex-duplex junction following UV irradiation. We have previously shown that a 15mer psoralen-oligonucleotide conjugate forming a triple helix on the promoter of the alpha subunit gene of the interleukin-2 receptor inhibits transcription of reporter plasmids tran...

Triple helix forming oligonucleotides can direct DNA damaging agents at specific sites in an intact double helix. In our study, triple helix formation was demonstrated in a SV40 based shuttle vector treated with psoralen linked to a 22-mer purine rich oligonucleotide. UVA irradiation caused a covalent linkage of the oligonucleotide through the psoralen to the mutational supF marker gene of the ...

The main aims of this paper are (a) to construct a generic conceptual model for the Triple Helix model based on competence sets and hence (b) to identify the systemlevel generic competencies needed in the emergence of a new industry. This paper suggests that to gain additional analytical leverage on the Triple Helix model, we need to study it also by focusing on generic competencies called for ...

One of the ways to develop Bima Ikat is by involving roles universities, government and business people known as triple helix model. This study aims analyze role government, academics in development woven textiles city Bima. research use desciptive qualitative approach. The population this were all weavers weaving village Ntobo sub-district, City sample used Quota sampling with a specified numb...

Theoretical background: The present article focuses on the assessment of readiness representatives science, business and local administration in Poland to establish mutual cooperation areas leadership, management style, competences technologies. Subject literature refers these three spheres as triple helix. literature, however, still lacks an cooperate from perspective administration. This belo...