نتایج جستجو برای: trimerization
تعداد نتایج: 507 فیلتر نتایج به سال:
We study the impact of trimerization (breathing) nearest-neighbor (NN) exchange on planar XY spin-1/2 ferromagnet kagome lattice, including additional four-site ring exchange. For uniform NN exchange, this model has previously been shown to transit from a long-range ordered into Z2 quantum spin liquid by virtue Using Monte-Carlo calculations, based stochastic series expansion, we present result...
The tetratricopeptide repeat (TPR) motif is a protein-protein interaction module that acts as an organizing centre for complexes regulating a multitude of biological processes. Despite accumulating evidence for the formation of TPR oligomers as an additional level of regulation there is a lack of structural and solution data explaining TPR self-association. In the present work we characterize t...
Glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) is part of a system of signals involved in controlling T-cell activation. Targeting and agonizing GITR in mice promotes antitumor immunity by enhancing the function of effector T cells and inhibiting regulatory T cells. Here, we describe MEDI1873, a novel hexameric human GITR agonist comprising an IgG1 Fc domain, a cor...
We have characterized the process by which the vesicular stomatitis virus (VSV) G protein acquires its final oligomeric structure using density-gradient centrifugation in mildly acidic sucrose gradients. The mature wild-type VSV G protein is a noncovalently associated trimer. Trimers are assembled from newly synthesized G monomers with a t1/2 of 6-8 min. To localize the site of trimerization an...
Multiple crystal structures of the homo-trimeric protein disulphide isomerase PmScsC reveal that peptide which links trimerization stalk and catalytic domain can adopt helical, β-strand loop conformations. This region has been called a ‘shape-shifter’ peptide. Characterisation this using NMR experiments MD simulations shown it is essentially disordered in solution. Analysis identifies role inte...
Whereas their para homologs are not mesogenic, the disk-shaped triphenyltriazine meta-trialkylesters obtained via trimerization of 3-cyanobenzoic alkylester, which configurationally more flexible, exhibit a monotropic nematic mesophase. Introduction fluorine atoms into alkyl chains or phenyl moieties leads to appearance an enantiotropic columnar If is introduced both in and moieties, only mesop...
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